Database: EMBASE <: international biomedical and pharmaceutical literature, 1988 - Aug 2000. [Trial access until 3/2001. Feedback welcome to medical.library@umich.edu] Search Strategy (You Saved Citations 1-23 From Set 67): ----------------------------------------------------------------------------- 1 exp Tooth demineralization/ 7753 2 demineralization.mp. 907 3 caries.mp. 1846 4 caires.mp. 0 5 craies.mp. 0 6 careis.mp. 1 7 carise.mp. 0 8 (teeth adj3 cavit:).mp. 32 9 (tooth adj3 cavit:).mp. 31 10 (dental adj3 cavit:).mp. 55 11 (dentin adj3 cavit:).mp. 14 12 (enamel adj3 cavit:).mp. 6 13 (teeth adj3 decay:).mp. 60 14 (tooth adj3 decay:).mp. 59 15 (dental adj3 decay:).mp. 48 16 (dentin adj3 decay:).mp. 0 17 (enamel adj3 decay:).mp. 1 18 (active adj decay).mp. 5 19 (rampant adj3 decay:).mp. 4 20 (recurrent adj3 decay:).mp. 3 21 (white adj spot:).mp. 229 22 carious.mp. 114 23 cariology.ti,ab. 2 24 (non-cavitated adj3 lesion:).mp. 0 25 (noncavitated adj3 lesion:).mp. 1 26 Tooth remineralization/ 819 27 (dental adj3 fissure:).mp. 7 28 (tooth adj3 fissure:).mp. 3 29 (teeth adj3 fissure:).mp. 1 30 caries-free.mp. 30 31 cariesfree.mp. 0 32 Cariogenic agents/ 3 33 precavit:.mp. 2 34 (filled adj3 teeth).mp. 47 35 (filled adj3 tooth).mp. 9 36 (oral adj fissure:).mp. 4 37 (tooth adj3 remineraliz:).mp. 1 38 (teeth adj3 remineraliz:).mp. 4 39 dft.mp. 583 40 dfs.mp. 1015 41 dmf:.mp. 1290 42 cariogeni:.mp. 169 43 or/1-42 12701 44 exp Genetics/ 10525 45 (cn or ge).fs. 87348 46 gene$1.mp. 441975 47 genetic:.mp. 235931 48 genom:.mp. 69641 49 genotyp:.mp. 27632 50 chromosom:.mp. 104283 51 congenit:.mp. 48604 52 familial.mp. 25779 53 heritab:.mp. 3554 54 inherit:.mp. 27009 55 twin$1.mp. 9553 56 Diseases in twins/ 2748 57 exp Multiple birth offspring/ 3143 58 consanguin:.mp. 2251 59 or/44-58 680672 60 43 and 59 1599 61 limit 60 to english language 1499 62 limit 61 to human 1114 63 exp Dentistry/ 2199 64 exp Dental care/ 6313 65 dent:.mp. 20519 66 or/63-65 22634 67 62 and 66 323 68 from 67 keep 1-300 300 69 from 67 keep 301-323 23 *************************** <1> UI - 1989206002 AU - Levin LS IN - Department of Otolaryngology-Head, Johns Hopkins University School of Medicine, Baltimore, MD 21205; United States. TI - Dental and oral abnormalities in selected ectodermal dysplasia syndromes. SO - Birth Defects: Original Article Series Vol 24(2) (pp 205-227), 1988. AB - The ectodermal dysplasias are a heterogeneous group of heritable disorders characterized by abnormalities of derivatives of the embryonic ectoderm. Controversy exists over which syndromes should be classified as ectodermal dysplasias and which should be excluded from the classification. In some ectodermal dysplasias, abnormalities in structures derived only from the ectoderm are found, while in others, structures derived from other germ layers are also affected. For example, the Ellis-van Creveld syndrome is characterized by abnormalities of the teeth and hair, as well as of the skeleton and the cardiovascular system. Whether to categorize this disorder as an ectodermal dysplasia or a skeletal is moot. Thus, classification is difficult because of our inability to satisfactorily define the clinical spectrum of these disorders. In fact, classification of the ectodermal dysplasias may have to be delayed until a more detailed understanding is obtained of the biochemical defects and of the complex epithelial-mesenchymal interactions that take place during embryologic and postnatal development. An ectodermal dysplasia will be defined as a heritable disorder in humans characterized by developmental abnormalities in at least two different ectodermally derived systems. In these disorders, the most frequently described oral abnormalities are of tooth number (primarily congenitally missing teeth) and of tooth shape. Defects of the enamel and oral soft tissues are documented less frequently, as are supernumerary teeth and abnormalities of dentin, pulp, and cementum. When appropriately evaluated, dental and oral soft tissue abnormalities may be useful in the diagnosis of the systemic disease with which they are associated and may be specific for the ectodermal dysplasia syndrome in question. Only a brief review of the dental and oral abnormalities in a few ectodermal dysplasia syndromes has been presented. Obviously, careful evaluation of the dentitions of patients suspected to have these disorders will add to our knowledge and assist in diagnosis of this heterogeneous group of genetic diseases. <2> UI - 1989175860 AU - Dahllof G AU - Ussisoo-Joandi R AU - Ideberg M AU - Modeer T IN - Department of Pedodontics, School of Dentistry, Karolinska Institute, 141 04 Huddinge; Sweden. TI - Caries, gingivitis, and dental abnormalities in preschool children with cleft lip and/or palate. SO - Cleft Palate Journal Vol 26(3) (pp 233-237), 1989. AB - Oral health was studied in 49 children aged 5 or 6 years old with clefts of the lip and/or palate (CL(P)) and 49 healthy controls matched for sex and age. The results showed a statistically significant increase in the prevalence and activity of caries in CL(P) children. The mean number of decayed and filled surfaces in the CL(P) group was 7.0 compared with 3.9 in the control group (p<0.05). The most evident difference between the two groups was found in the number of decayed proximal surfaces. The mean number of decayed proximal surfaces in the CL(P) group was 2.5, as compared with 0.9 in the control group (p<0.001). There were no significant differences in the caries prevalence and activity in children with clefts that involves the alveolus compared with those of children with isolated clefts of the lip or palate. The CL(P) children also exhibited a significant increase (p>0.01) in the number of gingival units with gingivitis. Other dental abnormalities included an increased frequency of enamel hypomineralization (p<0.05), supernumerary teeth (p<0.01), unilateral crossbite (p<0.001), mesial terminal plane (p<0.01), and crowding (p<0.001). The results show that the CL(P) children must be considered as a group with an increased caries risk and should therefore be subjected an additional preventive program. <3> UI - 1989163806 AU - Gazit D AU - Zeltser R AU - Galili D AU - Kaufman E IN - Division of Oral Pathology, Hebrew University Hadassah School of Dental Medicine, Jerusalem 91010; Israel. TI - Oral clinicopathologic manifestations in maple syrup urine disease. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 67(6) (pp 694-697), 1989. <4> UI - 1989149878 AU - Baden HP AU - Imber M IN - Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114; United States. TI - Ichthyosis with an unusual constellation of ectodermal dysplasias. SO - Clinical Genetics Vol 35(6) (pp 455-461), 1989. AB - A unique disorder characterized by ichthyosis and defects of the appendages and teeth is reported. Scaly skin and absence of sweating were observed shortly after birth. During childhood there was progressive loss of hair, severe abnormalities of dentition and dystrophic changes of the nails following minor trauma. The patient experienced corneal ulceration, and examination of the eyes revealed a reduced number of meibomian glands and changes in the cornea consistent with previous ulcers. Dryness of the mucous membranes of the mouth was also observed. There is no previous report of an individual with this constellation of changes. <5> UI - 1989129455 AU - Verhaaren H AU - Claeys G AU - Verschraegen G AU - De Niel C AU - Leroy J AU - Clement D IN - Department of Paediatrics, Division of Cardiology, University Hospital, Gent State University, 9000 Gent; Belgium. TI - Endocarditis from a dental focus. Importance of oral hygiene in valvar heart disease. SO - International Journal of Cardiology Vol 23(3) (pp 343-347), 1989. AB - Fastidiously growing bacteria more and more are recognised as a source of infectious endocarditis. Over recent years, three new cases of endocarditis caused by Actinobacillus actinomycetemcomitans were diagnosed in our institution. The rise in frequency is possible secondary to better laboratory skills. Two patients with Actinobacillus (Haemophilus) actinomycetemcomitans endocarditis presented the classical history of preexisting valvar disease together with poor dental hygiene. The third patient had no congenital or rheumatic preexisting lesion of the valves. The distal part of a ventriculo-atrial drainage device had caused microtrauma to the tricuspid valve. The right-sided endocarditis in this patient was complicated by pulmonary septic emboli. Dental origin of the infection was very likely in this patient too. No dental procedure had been performed in the months preceding the endocarditis of our three patients. They presented endocarditis with an oral microorganism in the absence of any dental manipulation. All three had very poor dental hygiene. Better dental care could possibly have prevented this serious complication. <6> UI - 1989104362 AU - Woods RJ AU - Sarre RG AU - Ctercteko GC AU - Jagelman DJ AU - Smith JW AU - Duchesneau PM AU - McGannon EA IN - Department of Colorectal Surgery, The Cleveland Clinic Foundation, Cleveland, OH; United States. TI - Occult radiologic changes in the skull and jaw in familial adenomatous polyposis coli. SO - Diseases of the Colon & Rectum Vol 32(4) (pp 304-306), 1989. AB - It has been suggested that radiology of the skull and jaw in familial polyposis coli may be a useful marker in up to 90 percent of cases. These x-rays were reviewed independently by a dental surgeon and a neuroradiologist in 51 patients. Only seven patients (14 percent) had significant lesion seen in the context of screening. Each of these patients also had other extracolonic manifestations of familial polyposis coli. The Cleveland Clinic Foundation experience with radiology of the jaw and skull is that it is not a useful screening tool. <7> UI - 1989096359 AU - Pinheiro M AU - Penna FJ AU - Freire-Maia N IN - Department of Genetics, Universidade Federal do Parana, 81504 Curitiba, PR; Brazil. TI - Two other cases of ANOTHER syndrome? Family report and update. SO - Clinical Genetics Vol 35(4) (pp 237-242), 1989. AB - We describe one daughter of a possibly distant consanguineous couple with infantile hyopthyroidism, trichodysplasia, dental anomalies, dystrophic nails, skin alterations, otitis media, slight conductive hypoacusia, recurrent respiratory tract infections, and gastroenterologic problems. One of her two sisters presents dental anomalies and trichodysplasia, and had dry skin at birth. Similarity indexes are estimated for our patients in comparison with those described under the acronym ANOTHER syndrome. It is concluded that, in spite of the differences, it is possible that our two patients also present ANOTHER syndrome. The cause is unknown. <8> UI - 1989095736 AU - Kanjilal D AU - Verma RS AU - Merkrebs A IN - Division of Genetics, Long Island College Hospital, Brooklyn, NY 11201; United States. TI - Clinical manifestation of children with a deletion of the short arm of chromosome 18 (18p-). SO - Dysmorphology & Clinical Genetics Vol 2(4) (pp 109-114), 1988. AB - A 15 [half] -year-old girl is reported with complete deletion of the short arm of chromosome 18, i.e., 46,XX, del (18) (p11). The major clinical features included mental retardation, growth retardation, dysmorphic facial features, protruding ears, low posterior hair line, severe dental caries, and behavioral abnormalities, e.g., restlessness, lack of concentration, emotional problems, unfriendly behavior, and psychosis. There are many cases of 18p- with delayed primary and secondary sexual development and amenorrhea, but this patient has normal sexual development and normal menstruation. Interestingly, she was referred to us to rule out Turner syndrome, and until the age of 13 years she was not suspected of having a chromosomal abnormality. After reviewing the current literature, we suggest that it is sometimes difficult to make a clinical diagnosis of 18p- without chromosomal analysis. <9> UI - 1989041158 AU - Caufield PW AU - Walker TM IN - Institute of Dental Research, University of Alabama, Birmingham, AL 35394; United States. TI - Genetic diversity within Streptococcus mutans evident from chromosomal DNA restriction fragment polymorphisms. SO - Journal of Clinical Microbiology Vol 27(2) (pp 274-278), 1989. AB - Attempts to study the acquisition, transmission, and other aspects of the natural history of Streptococcus mutans infections in humans have been hampered by limitations and inconsistencies in methods by which phenotypic characteristics of individual isolates are examined. Because most mutans streptococci associated with human dental caries fall within the biotype I (serotypes c and f) grouping, designated S. mutans, these typing methods are of little value in distinguishing individual isolates. Here we show that strains of S. mutans obtained from over 30 individuals demonstrate unique 'fingerprints' of chromosomal DNA digested with restriction endonuclease HaeIII. To demonstrate that this polymorphism in restriction fragment can be used to study the acquisition and transmission of this organism, we examined isolates of S. mutans from three mother-infant pairs obtained at the time the infant first became colonized by this organism. Results indicate that strains of S. mutans found in infants exhibit restriction fragment profiles identical to those of their mothers, strongly supporting the notion that mothers transmit this organism to their infants. Also, we show that strains of S. mutants with the same restriction fragment profile were stably maintained over a 3-year interval in the one mother-infant pair studied. Moreover, we found that mothers and their infants harbored only a few individual strains, suggesting that transmission of this organism is probably confined within discrete family cohorts. Collectively, these findings demonstrate the potential utility of genomic fingerprinting in studying the natural history of S. mutans infections in humans. <10> UI - 1989038779 AU - Bucci E AU - Muzio LL AU - Mignogna MD IN - Department of Oral Pathology, Universita degli Studi, II Facolta di Medicina e Chirurgia, Istituto di Discipline Odontostomatologiche, 80131 Napoli; Italy. TI - Oral and dental anomalies in Goltz syndrome. SO - Journal of Pedodontics Vol 13(2) (pp 161-168), 1989. <11> UI - 1989009912 AU - Levin LS AU - Young RJ AU - Pyeritz RE IN - Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21205; United States. TI - Osteogenesis imperfecta type I with unusual dental abnormalities. SO - American Journal of Medical Genetics Vol 31(4) (pp 921-932), 1988. AB - A large kindred with dominantly inherited osteogenesis imperfecta was evaluated. Affected individuals had bone fractures, blue sclerae, and hearing loss. In addition, all had dental abnormalities distinct from those previously described in other families with this syndrome. Deciduous teeth were normal in color or blue-grey. On radiographs of an early developing deciduous dentition, pulps were larger than normal. In patients with mixed dentitions, pulp chambers of deciduous teeth were partially obliterated. Increased constriction at the junctions of the crowns and roots was found in some deciduous teeth. One patient had large pulp stones in the pulp chambers of all maxillary deciduous molars. Permanent teeth were normal in color but had oval pulp chambers with apical extensions into the coronal portions of the roots, large coronal pulp stones, narrow root canals, and thin roots. Individual in this family who did not have osteogenesis imperfecta had normal teeth. In addition, a well circumscribed radiolucency without a sclerotic periphery, involving the apices of all permanent mandibular incisors, was found in the anterior mandible in one patient. These findings support the hypothesis that this family has yet another type I osteogenesis imperfecta 'syndrome'. <12> UI - 1989008728 AU - Svinhufvud E AU - Myllarniemi S AU - Norio R IN - Municipal Health Centre, Tuusula; Finland. TI - Dominant inheritance of tooth malpositions and their association to hypodontia. SO - Clinical Genetics Vol 34(6) (pp 373-381), 1988. AB - Four kindreds with family-specific malposition of cuspids were studied. Besides malposition of cuspids, the members also showed varying combinations of other anomalies: malposition, malformation or hypodontia of upper lateral incisors, second bicuspids and lower central incisors. The pedigrees provided convincing evidence for autosomal dominant transmission of the abnormalities studied. Their nature and location allow the assumption that they represent different expressions of one dominant gene causing a primary disturbance in the critical marginal area of the embryonic dental lamina. <13> UI - 1989007746 AU - Ranta R IN - Department of Pedodontics and Orthodontics, University of Helsinki, Helsinki; Finland. TI - Numeric anomalies of teeth in concomitant hypodontia and hyperdontia. SO - Journal of Craniofacial Genetics & Developmental Biology Vol 8(3) (pp 245-251), 1988. AB - Variations in tooth number in children, each of whom had supernumerary teeth and agenesis of teeth, is described. Among the 11, seven had cleft lip and palate, and two had clefting syndromes; two children had dental anomalies only. Only children who had both supernumerary teeth and congenitally missing teeth outside the area of the cleft alveolus were included. Concomitant hypodontia and hyperdontia were observed in the same dentition in nine subjects, in the same jaw in eight subjects, and in the same jaw quadrant in only three subjects. Supernumerary teeth and agenesis of teeth were observed simultaneously more often in the permanent dentitions than in the deciduous dentitions or in both dentitions simultaneously. The overall number of supernumeraries was 10 in the deciduous dentition and 14 in the permanent dentition of the 11 subjects. The number of congenitally absent teeth was 14 in the deciduous dentition and 40 in the permanent dentition. The etiology of concomitant hypodontia and hyperdontia is difficult to explain. It may result from disturbances in migration, proliferation, and differentiation of neural crest cells or interactions between the epithelial and mesenchymal cells during the initiation of odontogenesis. <14> UI - 1988235722 AU - Townsend GC AU - Richards LC AU - Brown T AU - Burgess VB IN - Department of Dentistry, University of Adelaide, Adelaide, SA 5001; Australia. TI - Twin zygosity determination on the basis of dental morphology. SO - Journal of Forensic Odonto-Stomatology Vol 6(1) (pp 1-15), 1988. AB - The zygosities of 120 pairs of South Australian twins were estimated by means of dental morphology and the findings compared with results of blood tests. Only three twin pairs (2,5%) were 'misclassified' on the basis of dental morphology, being identified as dizygous (DZ) whereas blood tests indicated monozygosity (MZ). Concordance for dental morphology was high within MZ pairs although certain teeth e.g. upper lateral incisors, upper second molars and lower second premolars often showed subtle variations in crown form. Detailed assessments of the expression of dental crown features are likely to assume greater importance in forensic investigations, particularly in countries where caries experience in decreasing. This study confirms the importance of genetic influences on crown morphology but indicates that environmental effects during odontogenesis contribute to the uniqueness of an individual's dentition. <15> UI - 1988175238 AU - Cecatto-De-Lima L AU - Pinheiro M AU - Freire-Maia N IN - Departamento de Genetica, Universidade Federal do Parana, 81504 Curitiba; Brazil. TI - Oculotrichodysplasia (OTD): A new probably autosomal recessive condition. SO - Journal of Medical Genetics Vol 25(6) (pp 430-432), 1988. AB - A brother and sister, the offspring of first cousins, are described with retinitis pigmentosa, trichodysplasia (hypotrichosis and structural changes), dental anomalies, and onychodysplasia. This is a pure ectodermal dysplasia of the tricho-odonto-onychial subgroup, probably due to an autosomal recessive gene. <16> UI - 1988145233 AU - Mahdi AH IN - College of Medicine, King Saud University, 11461 Riyadh; Saudi Arabia. TI - Osteopetrosis in Saudi children: A report of 10 cases. SO - Annals of Tropical Paediatrics Vol 8(2) (pp 112-115), 1988. AB - The case records of 10 children with osteopetrosis are reviewed. The mean age at presentation was 4 years. Parental consanguinity was noted in all the families. Growth retardation was the commonest presenting complaint. All the children had severe dental caries. Routine metabolic studies for calcium, phosphorus and alkaline phosphatase were unremarkable. The literature on the management of this entity is briefly discussed. <17> UI - 1988129015 AU - Lyons LA AU - Lewis RA AU - Strong LC AU - Zuckerbrod S AU - Ferrell RE IN - Department of Biostatistics, University of Pittsburgh, Pittsburgh, PA 15261; United States. TI - A genetic study of Gardner Syndrome and congenital hypertrophy of the retinal pigment epithelium. SO - American Journal of Human Genetics Vol 42(2) (pp 290-296), 1988. AB - Gardner Syndrome (GS) is an autosomal dominant variant of colorectal polyposis with essentially complete penetrance. It is distinguished from the other polyposis syndromes by its delayed age at onset, the number of polyps, and its extracolonic manifestations. The presence of epidermal cysts, bony osteomata, desmoid tumors, and dental anomalies are distinguishing features of this syndrome. Recently, multiple and bilateral patches of congenital hypertrophy of the retinal pigment epithelium (CHRPE) have been described in three families with classical GS. Tight linkage of the GS and CHRPE phenotypes (Z = 9.752; theta = 0) suggested that CHRPE is a pleiotropic effect of the Gardner mutation within the families in which the ophthalmic trait occurs and is thus a useful marker for the early detection of GS gene carriers. We have analyzed six new families segregating for classic GS and CHRPE. Linkage was tested between GS and CHRPE and between these two phenotypes and a battery of 22 informative biochemical and serological markers. We have extended the linkage analysis on two GS-CHRPE families originally reported elsewhere. Linkage between GS and CHRPE at theta = 0 was observed in all families, a result supporting our original suggestion that CHRPE is a congenital manifestation of the GS mutation. Exclusionary linkage data presented confirm that, for linkage analysis in these families, the CHRPE phenotype is a more powerful marker than other phenotypic features of GS. <18> UI - 1988115114 AU - Rakes GM AU - Panneton MJ AU - Kuster CG AU - Labart WA IN - Department of Pediatric Dentistry and Orthodontics, Boyne School of Dentistry, Creighton University, Omaha, NE 68178; United States. TI - Subacute bacterial endocarditis: Current perspectives. SO - Journal of Pedodontics Vol 12(3) (pp 223-229), 1988. <19> UI - 1988096309 AU - Nazzaro V AU - Blanchet-Bardon C AU - Mimoz C AU - Revuz J AU - Puissant A IN - Clinique des Maladies Cutanes, Hopital Saint-Louis, 74575 Paris Cedex 10; France. TI - Papillon-Lefevre syndrome. Ultrastructural study and successful treatment with acitretin. SO - Archives of Dermatology Vol 124(4) (pp 533-539), 1988. AB - Four siblings affected by Papillon-Lefevre syndrome (PLS) ranged in age from 2 to 11 years. The parents were unaffected and parental consanguinity was present. The 2-year-old girl showed the early manifestations of PLS; that is, slight gingival swelling and erythema occurring simultaneously with minimal scaling of palms and soles. The other siblings, aged 5, 8, and 11 years, showed severe periodontopathy with tooth loss and marked palmoplantar keratoderma with a centripetal extension of the keratoses to the limbs and trunk. These three older siblings were treated with acitretin (Ro 10-1670), the free acid of etretinate, with complete clearing of the skin and healing of gingival pockets. Treatment was given for 16 months; teeth that erupted during therapy were free of periodontopathy and remained firmly anchored to the alveolar bone. In two of the children ultrastructural examination of involved skin was performed before and during acitretin treatment. Before treatment a large number of lipidlike vacuoles were found in corneocytes and in granulocytes; tonofilaments were reduced in number, and keratohyaline granules frequently showed a rectangular or globular shape. During treatment with acitretin these abnormalities diminished markedly. Thus, etretin is effective in treating PLS and, if treatment is started at an early age, should allow patients with PLS to have normal adult dentition. <20> UI - 1988087718 AU - Wechsler MA AU - Papa CM AU - Haberman F AU - Marion RW IN - Genetic Counseling Program, Albert Einstein College of Medicine, Bronx, NY 10461; United States. TI - Variable expression in focal dermal hypoplasia. An example of differential X-chromosome inactivation. SO - American Journal of Diseases of Children Vol 142(3) (pp 297-300), 1988. AB - We encountered three women from three generations of the same family with features of focal dermal hypoplasia (FDH). Two of the patients, the proposita and her mother, demonstrated severe manifestations, including skin, dental, skeletal, and visceral abnormalities. The proposita's grandmother, the first family member affected, had very mild expression, with aplasia cutis congenita and dental caries as the only features expressed. This family illustrates both the marked variability of expression and the proposed X-linked dominant mode of inheritance of FDH. We postulate that early embryologic random inactivation of the X chromosome bearing the mutant gene responsible for FDH is the cause of the variable expression. <21> UI - 1988068060 AU - Walker PD IN - Microbial Culture Division, Wellcome Biotech, Beckenham BR3 3BS; United Kingdom. TI - Current trends and advances in bacterial vaccines today. SO - Journal of Applied Bacteriology Vol 62(1) (pp 1-23), 1987. <22> UI - 1988055966 AU - Burnett JW AU - Schwartz MF AU - Berberian BJ IN - Division of Dermatology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201; United States. TI - Ulerythema ophryogenes with multiple congenital anomalies. SO - Journal of the American Academy of Dermatology Vol 18(2 II SUPPL.) (pp 437-440), 1988. AB - Ulerythema ophryogenes, a rare dermatologic disorder characterized by inflammatory keratotic facial papules that may result in scars, atrophy, and alopecia, can occur in association with other congenital anomalies. A case reported here was accompanied by an unusual facies, developmental delay, central nervous system abnormalities, dental anomalies, and undescended testes. There was no response of the cutaneous lesions to topical keratolytics, topical tretinoin, or a short course of oral isotretinoin. <23> UI - 1988006964 AU - World Health Organization Geneva IN - Switzerland. TI - Prevention of oral diseases. SO - World Health Organization Offset Publication, Issue 103 (pp 1-83), 1987. AB - It is clear that combating oral disease mainly by increasing manpower and by improving treatment systems has not achieved the desired levels of oral health despite ever-increasing expenditure. This book promotes the far more successful preventive approach which can be implemented in countries at all levels of development. The three most important preventive measures are oral hygiene, optimal use of fluorides, and dietary control of sugars. Personal oral hygiene is the single most effective measure for periodontal disease prevention, and it also has an important role in caries prevention since fluorides can also be applied through personal care. Whereas community water fluoridation programmes require a certain technological sophistication, self care is effective, available to all, and thus of greater importance globally to improved oral health. The whole area of health education and promotion aimed at optimizing self-care and minimizing intervention is of prime importance in reinforcing the message offered by this book. The aim of this book is to provide oral health administrators and other personnel working with oral disease preventive programmes with a simple but comprehensive guide for their everyday work, from the design of a programme through to its evaluation. The objectives of this book are: to introduce the essential elements of the planning process, including manpower planning and costing; to encourage administrators to select appropriate preventive measures for their communities; to encourage planners and oral health personnel to evaluate and compare their results; to review current preventive programmes in given communities with a view to improving and extending them. This book is focused on primary prevention, as this is the most effective and desirable type of prevention, though some associated aspects of secondary or tertiary prevention are also included. This book, deals only with preventive programmes that are relevant to sizeable community problems and for which demonstrable improvements are attainable. Thus, it does not deal with genetic counselling for facial clefts or dentofacial anomalies, or with limitation of habits not clearly associated with oral diseases or conditions.