Database: EMBASE <: international biomedical and pharmaceutical literature, 1988 - Aug 2000. [Trial access until 3/2001. Feedback welcome to medical.library@umich.edu] Search Strategy (You Saved Citations 1-269 From Set 78): ----------------------------------------------------------------------------- 1 exp Hereditary diseases/ 157059 2 exp Skin diseases, genetic/ 190419 3 exp Bone diseases, developmental/ 5659 4 exp Tooth abnormalities/ 729 5 (amelogenesis adj imperfecta).mp. 57 6 (dens adj3 dente).mp. 1 7 odontodysplasia.mp. 5 8 (tricho adj dento adj osseous).mp. 10 9 (TDO adj syndrom:).mp. 4 10 anodontia.mp. 25 11 hypodontia.mp. 143 12 Osteogenesis imperfecta/ 906 13 exp Tooth diseases/ 7753 14 12 and 13 15 15 Dyskeratosis congenita/ 141 16 dyskeratosis.mp. 468 17 "Zinsser-Engman-Cole syndrome".mp. 2 18 HBID.mp. 1 19 or/15-18 468 20 Celiac disease/ 2827 21 (celiac or coeliac).mp. 5138 22 steatorrhea.mp. 625 23 sprue.mp. 270 24 (gluten adj enteropath:).mp. 30 25 or/20-24 5792 26 ((teeth or tooth or dent: or odonto: or enamel:) adj3 328 (imperfect: or hypoplasia or dysplasia or hypocalcificat:)).mp. 27 or/1-11,14,19,25-26 341133 28 exp Tooth demineralization/ 7753 29 demineralization.mp. 907 30 caries.mp. 1846 31 caires.mp. 0 32 craies.mp. 0 33 careis.mp. 1 34 carise.mp. 0 35 (teeth adj3 cavit:).mp. 32 36 (tooth adj3 cavit:).mp. 31 37 (dental adj3 cavit:).mp. 55 38 (dentin adj3 cavit:).mp. 14 39 (enamel adj3 cavit:).mp. 6 40 (teeth adj3 decay:).mp. 60 41 (tooth adj3 decay:).mp. 59 42 (dental adj3 decay:).mp. 48 43 (dentin adj3 decay:).mp. 0 44 (enamel adj3 decay:).mp. 1 45 (active adj decay).mp. 5 46 (rampant adj3 decay:).mp. 4 47 (recurrent adj3 decay:).mp. 3 48 (white adj spot:).mp. 229 49 carious.mp. 114 50 cariology.ti,ab. 2 51 (non-cavitated adj3 lesion:).mp. 0 52 (noncavitated adj3 lesion:).mp. 1 53 Tooth remineralization/ 819 54 (dental adj3 fissure:).mp. 7 55 (tooth adj3 fissure:).mp. 3 56 (teeth adj3 fissure:).mp. 1 57 caries-free.mp. 30 58 cariesfree.mp. 0 59 Cariogenic agents/ 3 60 precavit:.mp. 2 61 (filled adj3 teeth).mp. 47 62 (filled adj3 tooth).mp. 9 63 (oral adj fissure:).mp. 4 64 (tooth adj3 remineraliz:).mp. 1 65 (teeth adj3 remineraliz:).mp. 4 66 dft.mp. 583 67 dfs.mp. 1015 68 dmf:.mp. 1290 69 cariogeni:.mp. 169 70 or/28-69 12701 71 27 and 70 2074 72 limit 71 to english language 1846 73 limit 72 to human 1744 74 exp Dentistry/ 2199 75 exp Dental care/ 6313 76 dent:.mp. 20519 77 or/74-76 22634 78 73 and 77 569 79 from 78 keep 1-300 300 80 from 78 keep 301-569 269 *************************** <1> UI - 1994371747 AU - Blakey ML AU - Leslie TE AU - Reidy JP IN - Department of Sociology/Anthropology, Howard University,Washington, DC 20059; United States. TI - Frequency and chronological distribution of dental enamel hypoplasia in enslaved African Americans: A test of the weaning hypothesis. SO - American Journal of Physical Anthropology Vol 95(4) (pp 371-383), 1994. AB - The dentition of 27 enslaved African Americans from archaeological sites in Maryland and Virginia were examined. All 17 males and 7 of the 10 females in this study exhibited enamel hypoplastic defects indicative of systemic nutritional and disease stresses interfering with amelogenesis. Estimates of the ages of occurrence of these defects show that most occur between 1.5 and 4.5 years of age, 0.5-3.75 years later than historically documented weaning age (9-12 months of age) in similar plantation populations. Comparisons are made with studies of dental enamel hypoplasia in contemporaneous enslaved and free African American populations, including our data on 75 individuals from the First African Baptist Church cemetery in Philadelphia. These populations were highly stressed. While there appears to be a modest effect of early weaning stress, no direct relationship of peak frequencies to weaning age can be shown. These data raise questions about the attribution of peak hypoplasia frequencies to age at weaning or 'post-weaning' stresses in previous paleopathological studies. High hypoplasia frequencies during the middle years of enamel development are more likely the result of a combination of 1) multiple environmental stresses, 2) differences in hypoplastic susceptibility in enamel, and 3) random factors. <2> UI - 1994367059 AU - Sillence DO IN - Department of Genetics, The Children's Hospital,Camperdown, NSW 2050; Australia. TI - Craniocervical abnormalities in osteogenesis imperfecta: Genetic and molecular correlation. SO - Pediatric Radiology Vol 24(6) (pp 427-430), 1994. AB - Basilar impression (BI) assessed by either plain lateral skull radiograph or computerized tomography (CT) sagittal reconstruction of the craniocervical junction is a common finding occurring in 25% of subjects with osteogenesis imperfecta (OI). It appears to occur with highest frequency in a group of subjects with OI type IVB, i.e. patients with mild/moderate liability to fractures, normal sclerae but dentinogenesis imperfecta. Neurologic signs indicating compression of posterior fossa structures occur predominantly in subjects with BI and OI type IV. Screening is recommended for all patients with OI but particularly OI type IVB. <3> UI - 1994334407 AU - Papini M AU - Itin PH IN - Clinica Dermatologica R, Universita di Perugia, Ospedale S. Maria,I 05100 Terni; Italy. TI - Natural history of the Naegeli-Franceschetti-Jadassohn syndrome [6]. SO - Journal of the American Academy of Dermatology Vol 31(5 I) (pp 830), 1994. <4> UI - 1994334413 AU - Sahn EE AU - Davidson LS IN - Department of Dermatology, Medical University of South Carolina, 171 Ashley Ave.,Charleston, SC 29425-2215; United States. TI - Incontinentia pigmenti: Three cases with unusual features. SO - Journal of the American Academy of Dermatology Vol 31(II) (pp 852-857), 1994. AB - Three patients with incontinentia pigmenti are described who illustrate some of the unusual features of this uncommon genodermatosis. One child with skin, ophthalmologic, and dental findings had atrophic, hypopigmented streaks on her legs by the age of 2 [half] years that were consistent with the fourth stage of incontinentia pigmenti. This child's mother, who also had incontinentia pigmenti, had identical atrophic streaks on the legs, as well as irregular axillary pigmentation, scarring alopecia, and dental abnormalities. A second child is described who had annular blisters, persistent verrucous plaques, whorled hyperpigmentation, and dental abnormalities. <5> UI - 1994339081 AU - Soekarman D AU - Volcke P AU - Fryns J-P IN - Centre for Human Genetics, Herestraat 49,B-3000 Leuven; Belgium. TI - The KBG syndrome: Follow-up data on three affected brothers. SO - Clinical Genetics Vol 46(4) (pp 283-286), 1994. AB - In this report we present follow-up data on a family in which several members were found to have short stature, craniofacial anomalies and dento-skeletal abnormalities (KBG-syndrome). As adults, the three affected brothers of the original report are moderately to severely mentally retarded. Their phenotype with a distinct craniofacial appearance did not change much from that seen during childhood and adolescence. Adult height is far below the third centile, with arm spans exceeding stature by at least 9 cm. <6> UI - 1994328619 AU - Figuera LE AU - Ramirez-Duenas ML AU - Rivera H IN - Division de Genetica, UIBO-IMSS, Ap Postal 1-3838,Guadalajara, Jalisco; Mexico. TI - The Ohdo blepharophimosis syndrome in a Mexican boy. SO - Dysmorphology & Clinical Genetics Vol 6(4) (pp 196-198), 1992. AB - The clinical picture of a 16-month-old Mexican boy (hypotonia, psychomotor retardation, blepharophimosis, small and widely spaced teeth, hypoplastic scrotum) was compatible with the diagnosis of Ohdo blepharophimosis syndrome (OBS). Comparison with six previously described patients confirms that the OBS is mainly characterized by psychomotor and mental retardation, blepharophimosis, dental hypoplasia, deafness, and hypoplastic scrotum. The advanced age of this boy's father suggests a possible autosomal dominant mutation in the syndrome. <7> UI - 1994326489 AU - Hart TC AU - Kyrkanides S IN - Department of Dentistry, Bowman-Gray School of Medicine, Medical Center Blvd,Winston-Salem, NC 27157; United States. TI - Cephalometric analysis of Rapp-Hodgkin syndrome. SO - Journal of Medical Genetics Vol 31(10) (pp 758-760), 1994. AB - Rapp-Hodgkin syndrome (RHS) is a rare form of ectodermal dysplasia with variable involvement of the hair, eyes, sweat glands, nails, and teeth. Oral findings may include hypodontia, hypoplastic enamel, cleft lip/palate, and a pronounced midfacial hypoplasia. The objective of this study was to determine if the pronounced midfacial hypoplasia is the result of a true tissue hypoplasia or displacement of midfacial tissues. We have identified a family in which three members, a mother and two daughters, display clinical features characteristic of RHS. Clinical and intraoral examination of these affected persons showed manifestations characteristic of RHS, and several new findings were observed, including subcutaneous abscesses, palmoplantar keratosis, and keratotic lesions located on the chest and trunk. To assess the midfacial hypoplasia. lateral cephalometric analysis was performed on lateral headplates. Results of the cephalometric analysis suggest that the midfacial hypoplasia results from both a deficiency and a displacement of the maxilla. These findings are significant because successful dental treatment of RHS relies upon accurate assessment of current and projected orofacial development, particularly for the skeletal relations of the maxilla and mandible. <8> UI - 1994301238 AU - Jiroutova O AU - Mullerova Z IN - Srobarova 50,100 34 Prague 50; Czech Republic. TI - The occurrence of hypodontia in patients with cleft lip and/or palate. SO - Acta Chirurgiae Plasticae Vol 36(2) (pp 53-56), 1994. AB - The frequency of hypodontia (but for the third molar) was studied in a series of 600 patients with cleft lip and/or palate. The series was subdivided into three groups according to the type of facial cleft. As compared to the general normal population the occurrence of hypodontia was markedly increased in patients with clefts. The highest percentage of hypodontia was recorded in patients with cleft lip and palate, the lowest frequency was present in cleft lip only. In cleft lip and in cleft lip and palate girls were affected significantly more frequently than boys. The occurrence of hypodontia in the lower and in the upper jaw differed according to the type of cleft. The upper jaw was affected more often in cleft lip and in cleft lip and palate, the mandible was involved more frequently in isolated cleft palate. The dental bud of the upper lateral incisor was affected most commonly in cleft lip and in cleft lip and palate, while the second lower premolar was most frequently absent in isolated cleft palate. <9> UI - 1994305056 AU - Bartsch O AU - Tympner K-D AU - Schwinger E AU - Gorlin RJ IN - Institut fur Klinische Genetik, Universitatsklinikum, Carl Gustav Carus Technischen Univ, Fetscherstrasse 74,01307 Dresden; Germany. TI - Mulvihill-Smith syndrome: Case report and review. SO - Journal of Medical Genetics Vol 31(9) (pp 707-711), 1994. AB - We report a 20 year old man with short stature, microcephaly, unusual facies, numerous pigmented naevi, hypodontia, immunodeficiency, and a high pitched voice. Tympner et al had assumed that the patient had a new syndrome of 'progressive combined immunodeficiency and ectomesodermal dysplasia'. We show here that the condition is identical to the Mulvihill-Smith syndrome (McKusick 176690), a progeroid disorder described in four or possibly five sporadic cases to date. We describe his clinical progress up to the age of 20 years. Our patient suffered from severe viral infections, allergic rhinitis and conjunctivitis, delayed puberty, visual loss, modest achievement in high school, and reactive depression. The immunological, facioskeletal, and dental abnormalities are presented in detail. <10> UI - 1994305050 AU - Munro CS AU - Carter S AU - Bryce S AU - Hall M AU - Rees JL AU - Kunkeler L AU - Stephenson A AU - Strachan T IN - Department of Human Genetics, University of Newcastle upon Tyne, Claremont Place,Newcastle upon Tyne NE1 7RU; United Kingdom. TI - A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21. SO - Journal of Medical Genetics Vol 31(9) (pp 675-678), 1994. AB - Pachyonychia congenita (PC) is a group of hereditary syndromes which have in common a hypertrophic dystrophy of the distal nail, and are associated with a variety of additional features, notably various dyskeratoses of skin and mucous membranes. The pathology is unknown but the array of clinical features suggests the possibility of a keratin abnormality. In the present report we describe linkage analyses in a large PC pedigree of the Jackson-Lawler type, a subtype which is characterised by multiple epidermal cysts, hair abnormalities, and natal teeth. The disease locus in this family was found to be tightly linked to markers mapping within, or very close to, the keratin type I cluster at 17q12-q21; maximum lod scores for linkage of the disease to a KRT10 polymorphism and to D17S800, a marker known to be very tightly linked to KRT10, were respectively +4.51 and +7.73, both at theta=0.00. Although always likely, our findings provide strong evidence of a keratin gene anomaly underlying an inherited disorder affecting epidermis, nail, hair, and mucosa. These findings permit testing to see if pachyonychia congenita shows any locus heterogeneity and suggest specific candidate keratin genes for mutation searching studies. In addition, they suggest a role for keratins in the phenomenon of natal dentition. <11> UI - 1994304156 AU - Forsman K AU - Lind L AU - Backman B AU - Westermark E AU - Holmgren G IN - Department of Clinical Genetics, University Hospital,S-901 85 Umea; Sweden. TI - Localization of a gene for autosomal dominant amelogenesis imperfecta (ADAI) to chromosome 4q. SO - Human Molecular Genetics Vol 3(9) (pp 1621-1625), 1994. AB - Amelogenesis imperfecta (AI)l is an inherited odontological disease which affects the formation of enamel. We report a linkage analysis study performed on three Swedish families, where the affected members had an autosomal dominant variant of AI (ADAI) clinically characterized as local hypoplastic. Significant linkage to microsatellite markers on chromosome 4q were obtained. Recombinations localized the ADAI locus to a chromosome region which contains both a locus for the dental disorder dentinogenesis imperfecta and the albumin gene. Serum albumin has been suggested to play a role in enamel formation, and the albumin gene is therefore a candidate gene for this genetic disease. <12> UI - 1994282420 AU - Greenspan D AU - Greenspan JS IN - Department of Stomatology, UCSF, Box 0422,San Francisco, CA 94143-0422; United States. TI - The mouth in human immunodeficiency virus infection. SO - Seminars in Dermatology Vol 13(2) (pp 144-150), 1994. AB - Oral manifestations are a common feature of human immunodeficiency virus (HIV) infection. They may present as neoplasms, opportunistic infections, or other lesions. The dermatologist may be the first health care provider to suspect HIV infection when recognizing some of the oral lesions described in this article. Some of these lesions may be of prognostic significance for the subsequent development of AIDS. Management of the oral lesions can significantly reduce morbidity and improve quality of life. <13> UI - 1994282414 AU - Wright JT AU - Fine J-D IN - Department of Pediatric Dentistry, School of Dentistry, University of North Carolina,Chapel Hill, NC 27599; United States. TI - Hereditary epidermolysis bullosa. SO - Seminars in Dermatology Vol 13(2) (pp 102-107), 1994. AB - Epidermolysis bullosa (EB) is a diverse group of disorders having blister formation as their common feature. Tissue separation occurs at variable depths in the skin and/or mucosa depending on the specific EB type. Marked oral involvement of the soft and hard tissues can produce potentially devastating alterations, with oral tissue fragility and blistering common to all EB types. Oral debilitation resulting from soft tissue scarring is limited primarily to the recessive dystrophic EB subtypes. Individuals with generalized recessive dystrophic EB typically have microstomia, obliteration of the oral vestibule, and ankyloglossia. Generalized enamel hypoplasia appears to be limited to junctional EB, whereas rampant dental caries afflicts many individuals having either junctional or generalized recessive dystrophic EB. Although systemic treatment remains primarily palliative, it is possible to prevent destruction and subsequent loss of the dentition through appropriate interventions and dental therapy. The severely affected soft and/or hard tissues frequently seen in patients having generalized recessive dystrophic and junctional EB often require aggressive dental intervention to maintain optimal oral health. Even the most severely affected individuals with EB can retain their dentition through the use of modern dental restorative techniques delivered using general anesthesia. <14> UI - 1994281020 AU - Kirkpatrick CH IN - Innovative Therapeutics, Inc., 4860 N. Broadway,Denver, CO 80216-6344; United States. TI - Chronic mucocutaneous candidiasis. SO - Journal of the American Academy of Dermatology Vol 31(3 II) (pp S14-S17), 1994. AB - Chronic mucocutaneous candidiasis is a complex disorder in which patients have chronic and recurrent Candida albicans infections of the skin, nails, and mucous membranes. There are several subgroups of patients with chronic mucocutaneous candidiasis, and these can be identified by associated disorders such as autoimmune diseases, endocrinopathies, thymoma, and interstitial keratitis, as well as the distribution and severity of the Candida infections. Several other disorders may coexist in patients with chronic mucocutaneous candidiasis. These include other infectious diseases, endocrinopathies, dental enamel dysplasia, vitiligo, and alopecia totalis. Successful treatment programs should include antifungal drugs and manipulations that correct the immunologic abnormalities that predispose the patient to Candida infections. <15> UI - 1994270158 AU - Bains JW AU - Elia JP IN - 3333 E. Camelback Road,Phoenix, AZ 85018; United States. TI - The role of facial skeletal augmentation and dental restoration in facial rejuvenation. SO - Aesthetic Plastic Surgery Vol 18(3) (pp 243-246), 1994. AB - Facial aging is almost exclusively a result of soft tissue changes in patients with full dentition. Loss of teeth can hasten facial aging and make aging more pronounced as a result of bony erosion of the alveolar ridges. This article describes these changes and demonstrates that properly selected oral implants and precisely placed hydroxyapatite implants can integrate with facelifts to produce superior facial rejuvenation in edentulous patients. <16> UI - 1994269204 AU - Markham A AU - Faulds D IN - Adis Limited, 41 Centorian Drive,Mairangi Bay, Auckland 10; New Zealand. TI - Roxithromycin: An update of its antimicrobial activity, pharmacokinetic properties and therapeutic use. SO - Drugs Vol 48(2) (pp 297-326), 1994. AB - Roxithromycin is a derivative of the macrolide antibacterial erythromycin with vitro antibacterial activity resembling that of the parent compound. The drug has activity against some Staphylococcus spp., many Streptococcus spp., Moraxella (Branhamella) catarrhalis, Mycoplasma pneumoniae, Legionella pneumophila and Chlamydia trachomatis as well as many less common organisms. Measured using recently proposed guidelines, roxithromycin has in vitro activity against Haemophilus influenzae. In comparison with that of its parent compound, the pharmacokinetic profile of roxithromycin is characterised by high plasma, tissue and body fluid concentrations and a long half-life permitting an extended dosage interval. Roxithromycin has proven clinical efficacy in upper and lower respiratory infections, skin and soft tissue infections, urogenital infections and orodental infections, and appears to be as effective as more established treatments including erythromycin, amoxicillin/clavulanic acid and cefaclor. The drug has also shown promise in a variety of more specialised indications including opportunistic infections in human immunodeficiency virus (HIV)-positive patients and as part of a Helicobacter pylori eradication regimen. Roxithromycin is very well tolerated with an overall incidence of adverse effects of approximately 4%. Thus, roxithromycin is an attractive therapeutic alternative in its established indications, especially when the option of once-daily administration is considered. <17> UI - 1994258702 AU - Gregor RT AU - Loftus-Coll B IN - The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121,1066 CX Amsterdam; Netherlands. TI - Myxoma of the paranasal sinuses. SO - Journal of Laryngology & Otology Vol 108(8) (pp 679-681), 1994. AB - Myxomas of the paranasal sinuses are rare but well described in the literature. They may be related to dental malformations or missing teeth, but may also occur without any such abnormalities. Their local aggressiveness and ability to erode bone should not be underestimated, and they should be totally removed whenever possible. A case of myxoma of the sinuses is described, in which recurrence followed several local removals. The patient was only cured by radical maxillectomy. The operation is described, and the literature on the subject reviewed. <18> UI - 1994213857 AU - Kodali VRR AU - Krishnamachari KAVR AU - Gowrinathsastry J IN - Apollo Hospital, Muthukuru Road,Nellore-524 004; India. TI - Detrimental effects of high fluoride concentrations in drinking water on teeth in an endemic fluorosis area in south India. SO - Tropical Doctor Vol 24(3) (pp 136-137), 1994. <19> UI - 1994191006 AU - Kaste SC AU - Hopkins KP AU - Jenkins III JJ IN - Department of Diagnostic Imaging, St. Jude Children's Research Hosp., 332 N. Lauderdale,Memphis, TN 38105; United States. TI - Abnormal odontogenesis in children treated with radiation and chemotherapy: Imaging findings. SO - American Journal of Roentgenology Vol 162(6) (pp 1407-1411), 1994. AB - Contemporary oncotherapy has improved survival of children with malignant diseases, but chemotherapy and radiotherapy also have deleterious effects. This essay illustrates the effects of chemotherapy and radiotherapy on dentition in children and adolescents. The illustrated abnormalities were seen on panoramic radiographs obtained before, during, and after treatment. Included are examples of hypodontia (partial anodontia), microdontia, altered eruption patterns, and root stunting. Comparison is made with normal dental development <20> UI - 1994174254 AU - Monson ML IN - Dental Service, VAMC Sepulveda, 16111 Plummer St,Sepulveda, CA 91343; United States. TI - Diagnostic and surgical guides for placement of dental implants. SO - Journal of Oral & Maxillofacial Surgery Vol 52(6) (pp 642-645), 1994. <21> UI - 1994178064 AU - Sener RN IN - Department of Radiology, Ege University Hospital,Bornova, TR-35100 Izmir; Turkey. TI - Polycystic brain (cerebrum polycystica vera) associated with ectodermal dysplasia: A new neurocutaneous syndrome. SO - Pediatric Radiology Vol 24(2) (pp 116-118), 1994. AB - This paper presents a unique case of true polycystic brain in which multiple cysts of curvilinear, round oval, or layered configuration occurred. These apparently represented extremely dilated Virchow-Robin spaces: the perivascular spaces lined by ependymal/leptomeningeal cells. Irregular retinal pigment epithelium was also evident. In addition, the patient showed ectodermal dysplasia manifesting as thin hair, dystrophic nails, and dental abnormalities. A common ectodermal origin for the brain cysts and the ectodermal changes is proposed, as it is known that the central nervous system (including the ependymal/leptomeningeal cells and the retinal cells), the epidermis (including hair and nails), and the enamel of the teeth have the same origin - the embryonic ectoderm. This association appears to be a new, distinct neurocutaneous syndrome. <22> UI - 1994177693 AU - Mottes M AU - Sangalli A AU - Valli M AU - Forlino A AU - Gomez-Lira M AU - Antoniazzi F AU - Constantinou-Deltas CD AU - Cetta G AU - Pignatti PF IN - Istituto di Scienze Biologiche, Universita di Verona, Strada Le Grazie,I-37134 Verona; Italy. TI - A base substitution at IVS-19 3'-end splice junction causes exon 20 skipping in proalpha2(I) collagen mRNA and produces mild osteogenesis imperfecta. SO - Human Genetics Vol 93(6) (pp 681-687), 1994. AB - Molecular investigations on a young patient and her family were undertaken to identify the molecular defect responsible for a mild form of osteogenesis imperfecta (OI) with blue sclerae, dentinogenesis imperfecta and joint laxity. Analysis of collagenous proteins from the proband's fibroblasts showed the presence of two populations of alpha2(I) chains, one normal and one migrating faster on SDS gels, thereby suggesting deletion of amino acid sequences. The faster migrating chains were retained mainly in the cell layer and not found in the extracellular matrix deposited by cultured fibroblasts. Chemical cleavage of mismatch (CCM) analysis on the patient's proalpha2(I) mRNA: normal cDNA heteroduplexes localized the molecular defect. cDNA sequencing revealed a deletion of exon 20 (54 bp) in about half of the molecules. Genomic DNA sequencing revealed heterozygosity for a G-to-C transversion of the last nucleotide of intron 19, which changed the 3 consensus splicing site. As a consequence proalpha2(I)mRNA was abnormally spliced from the last codon of exon 19 to the first codon of exon 21. To our knowledge, this is the first acceptor site mutation so far described in an OI patient. Restriction analysis indicated that the mutation was present also in three other affected family members. The full sequence of COL1A2 introns 19 and 20 are reported. <23> UI - 1994142656 AU - Querna JC AU - Rossmann JA AU - Kerns DG IN - U.S. Army Dental Activity,Fort Benning, GA 31905; United States. TI - Prevalence of periodontal disease in an active duty military population as indicated by an experimental periodontal index. SO - Military Medicine Vol 159(3) (pp 233-236), 1994. AB - An experimental periodontal screening examination and index was used to measure the prevalence of gingivitis and periodontitis among 1,334 soldiers at Fort Knox, Kentucky. Although 12.1% of the subjects demonstrated no disease, 40.3% were found to have gingivitis. In this sample group, the occurrence of gingivitis decreased with increasing age. Early periodontitis (probing depths of 3-5 mm) was detected in 35.7% of the subjects, and subjects with moderate to advanced periodontitis (probing depths greater than 5 mm) comprised 11.9% of the sample. The screening exam used is suggested for use as part of each soldier's annual dental examination. <24> UI - 1994140924 AU - Sperber GH AU - Machin GA AU - Bamforth FJ IN - Faculty of Dentistry, University of Alberta,Edmonton, Alta. T6G 2N8; Canada. TI - Mirror-image dental fusion and discordance in monozygotic twins. SO - American Journal of Medical Genetics Vol 51(1) (pp 41-45), 1994. AB - A pair of monozygotic twins had similar but not identical dental anomalies. One twin had fusion of deciduous mandibular lateral incisor and canine on the left, with normal dentition on the right; the co-twin had right mandibular incisor/canine fusion, with aplasia of the lateral incisor on the left. These findings are discussed in the context of the related phenomena of situs inversus, mirror-imaging in twins, and gradients of severity of anomalies in the four copies of the mandibular developmental dental field. <25> UI - 1994132655 AU - Maat-Kievit JA AU - Milla PJ AU - Collins JE AU - Baraitser M AU - Winter RM IN - Mothercare Unit of Clinical Genetics, Institute of Child Health, 30 Guilford Street,London WC1N 1EH; United Kingdom. TI - A case with blepharophimosis resembling Ohdo syndrome. SO - Clinical Dysmorphology Vol 3(2) (pp 125-127), 1994. AB - Another possible sporadic case of the Ohdo blepharophimosis syndrome is described and compared with the seven patients previously reported. It can be considered a distinctive syndrome showing blepharophimosis, ptosis, dental hypoplasia, mental retardation and deafness. This case helps to define the spectrum of the phenotypic anomalies. <26> UI - 1994132405 AU - Ishikawa I AU - Umeda M AU - Laosrisin N IN - Department of Periodontology, School of Densitry, Tokyo Medical and Dental University,Bunkyo-ku, Tokyo 113; Japan. TI - Clinical, bacteriological, and immunological examinations and the treatment process of two Papillon-Lefevre syndrome patients. SO - Journal of Periodontology Vol 65(4) (pp 364-371), 1994. AB - Papillon-Lefevre syndrome (PLS) is a rare disease with the early onset of periodontal breakdown in deciduous and permanent dentition. The etiology of the destruction has not been completely clarified. Two female patients (ages 4 and 7 years) with severe destruction of the periodontal structures were examined. Except for palmar and plantar hyperkeratosis, dermatologic examination revealed no other medical disorders. On immunological analysis, measurement of serum antibody titers to 7 periodontopathic bacteria including Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans was performed by enzyme-linked immunosorbent assay (ELISA). Further immunblot analysis of A. actinomycetemcomitans and microbial culture of samples collected from deep periodontal pockets and mouthrinse solution were performed. The serum of the two patients showed high IgG titer against A. actinomycetemcomitans. Immunoblot results of the two patients against sonicated extract of A. actinomycetemcomitans Y4 strain exhibited a similar pattern. The band pattern differed from that observed in other forms of early onset periodontitis patients or periodontally healthy subjects. Moreover, A. actinomycetemcomitans colonies were cultured in high percentages from the pocket samples. Antibiotic therapy was instituted in addition to conventional periodontal therapy. In the younger patient, all deciduous teeth were extracted as part of the treatment and A. actinomycetemcomitans was no longer detected. All four permanent first molars and 8 permanent incisors subsequently erupted with healthy periodontium. However, the older patient did not improve after periodontal and antibiotic (minocycline and erythromycin) treatments and A. actinomycetemcomitans was consistently detected. Ofloxacin medication finally eliminated A. actinomycetemcomitans from the periodontal pockets. This antibiotic was also associated with reduced gingival inflammation and probing depth. Further destruction of the periodontium has not been detected for 3 years. The serum IgG titers against A. actinomycetemcomitans decreased in both patients. It is suggested that A. actinomycetemcomitans is a major pathogen closely related to periodontal tissue destruction in PLS patients. <27> UI - 1994125041 AU - Herrstrom P AU - Hogstedt B IN - Hertig Knut Health Centre, Bryggaregatan 1,S-302 43 Halmstad; Sweden. TI - Allergic diseases, dental health, and socioeconomic situation of Swedish teenagers: Allergy, dental health, and social situation. SO - Scandinavian Journal of Primary Health Care Vol 12(1) (pp 57-61), 1994. AB - Objective - To study the association between allergic diseases (eczema, allergic rhino-conjunctivitis, and asthma), dental health, and the socioeconomic situation of Swedish teenagers. Design - Cross-sectional survey with a questionnaire for allergic symptoms and parents' occupation (for socioeconomic classification); current dental status from the Public Dental Service. Bronchial reversibility test. Telephone inquiry of asthma cases. Setting - Primary care and a school in the centre of a middle-sized Swedish town (approx. 80,000 inhabitants). Participants - 137 pupils of both sexes, 13 - 15 years old. Main outcome measures - Number of reported cases with allergic disease and outcome of bronchial reversibility test in relation to social class. Number of validated cases of asthma. Number of filled tooth surfaces in healthy and diseased cases. Results - Socioeconomic situation was found to associate with dental health, i.e. more fillings in lower social classes (P=0.01), and with allergic disease, i.e. asthma and rhino- conjunctivitis (P=0.05). Individuals from the upper social classes seemed prone to overreport asthmatic symptoms, whereas teenagers in the lower classes did the opposite, as indicated by five cases of pathologic values after bronchial reversibility tests in individuals who did not report asthmatic symptoms. Conclusion - The study indicates that socioeconomic situation associates significantly with both dental health and allergic disease. No association was found between dental health and allergic diseases. <28> UI - 1994125032 AU - Herrstrom P AU - Hogstedt B IN - Hertig Knut Health Centre, Bryggaregatan 1,S-302 43 Halmstad; Sweden. TI - Dental restorative materials and the prevalence of eczema, allergic rhino- conjunctivitis, and asthma in schoolchildren: Dental amalgam and allergy in schoolchildren. SO - Scandinavian Journal of Primary Health Care Vol 12(1) (pp 3-8), 1994. AB - Objective - To study the association between allergic diseases (eczema, allergic rhino-conjunctivitis, and asthma) and different types of dental restorative materials (amalgam, composite, and glass ionomer) in Swedish schoolchildren. Design - Cross-sectional survey with a questionnaire asking for symptoms of allergic disease during the previous year. This information was combined with current dental status (number and type of filled tooth surfaces). Setting - Primary care and a school in the centre of a middle- sized Swedish town (approx. 80,000 inhabitants). Participants - 348 pupils of both sexes 13 - 15 years old. Outcome measures - The occurrence of allergic disease in pupils with and without dental fillings of different types. The mean number and type of filled tooth surfaces in diseased and healthy pupils. Results - 44% of the pupils had no amalgam fillings. This group of children reported significantly more often asthmatic symptoms than the group with amalgam (P=0.02). The asthmatic children had a lower mean number of amalgam surfaces than the other pupils (P=0.002) and also a lower mean number of filled tooth surfaces of all types. Conclusion - The results of this study do not support the theory that amalgam fillings increase the prevalence of allergic diseases or allergic reactivity as such in schoolchildren. Neither do composite and glass ionomer seem to cause such complications. <29> UI - 1994133079 AU - Braga D AU - Manganoni AM AU - Gavazzoni R AU - Pasolini G AU - De Panfilis G IN - Divisione Dermatologia, Spedali Civili,I-25125 Brescia; Italy. TI - A case of trichorhinophalangeal syndrome, type I. SO - Cutis Vol 53(2) (pp 92-94), 1994. AB - A single case of trichorhinophalangeal syndrome, type I, is reported. The patient manifested the complete triad of the syndrome: thin, sparse, slow- growing scalp hairs; a pear-shaped nose; and cone-shaped epiphysis in some interphalangeal articulations of both hands. In addition, tooth decay, pectus carinatum, lumbar scoliosis, and polycystic ovary were observed. This multisystemic disorder is apparently rare, but its prevalence is probably underestimated in the dermatologic literature. <30> UI - 1994111441 AU - Tak Kun Chow IN - Department of Dentistry, United Christian Hospital, 130 Hip Wo Street,Kwun Tong; Hong Kong. TI - Survey of 300 Chinese cleft palate patients presenting for recall to a Dental Department in Hong Kong. SO - Cleft Palate-Craniofacial Journal Vol 31(2) (pp 146-147), 1994. AB - Three hundred Chinese patients with cleft lip and/or palate were reviewed in the Dentofacial Deformities Clinic of the Department of Dentistry at the United Christian Hospital between January 1990 and January 1992. A survey was taken of patients' age, sex, type of cleft, and cleft location. The findings from this survey are compared to an original sample of 2800 cleft patients surveyed earlier. <31> UI - 1994111440 AU - Morris T AU - Roberts C AU - Shaw WC IN - Department of Orthodontics, Univ. Dental Hospital of Manchester, Higher Cambridge Street,Manchester M15 6FH; United Kingdom. TI - Incisal overjet as an outcome measure in unilateral cleft lip and palate management. SO - Cleft Palate-Craniofacial Journal Vol 31(2) (pp 142-145), 1994. AB - The Goslon Yardstick is a clinical tool used to rank dental study casts of persons with cleft lip and palate in the late mixed or early permanent dentition into one of five categories. It has been successfully used to investigate the outcomes of the surgical treatment of these anomalies as well as the effects of these deformities on untreated individuals. In this study, 40 study casts ranked by the Goslon Yardstick were digitized using a reflex metrograph. The overjet, overbite, and incisal angulation, and the crossbites of the canines and molars were calculated for each of the sets of casts. Multiple regression analysis was used to determine the predictive value of these variables upon the Goslon scores. The overjet was found to explain 87% of the variance of the Goslon score (p < .0001). No other component had a significant predictive value. The range of overjet associated with the different Goslon scores was calculated from the regression equation. In conclusion, the advantages of using overjet as an indicator of outcome as an alternative to the Goslon Yardstick were discussed. <32> UI - 1994109423 AU - Abdel-Al YK AU - Shabani IS AU - Lubani MM AU - Al-Ghawabi MA AU - Ibrahim MD AU - Al-Mohtaseb S AU - Duodin KI IN - Department of Paediatrics, Adan Hospital,Kuwait; Kuwait. TI - Autosomal recessive osteopetrosis in Arab children. SO - Annals of Tropical Paediatrics Vol 14(1) (pp 59-64), 1994. AB - Nineteen Arab children including six boys and 13 girls in ten sibships were diagnosed as having osteopetrosis over a 5-year period in various hospitals in Kuwait. Eighteen patients had an isolated autosomal recessive form and one had autosomal recessive osteopetrosis associated with renal tubular acidosis. The mean age of diagnosis was 24 months. Parental consanguinity was high amongst them (68%). Anaemia, hepatosplenomegaly, failure to thrive, recurrent infections and neurological manifestations were common. Associated congenital abnormalities were found in 26%. Deafness, hydrocephalus and dental caries were relatively less common. A high mortality (37%) owing to infection was noted. The medical management and recommendations for patient care are discussed briefly. <33> UI - 1994108477 AU - Francannet C AU - Vanlieferinghen P AU - Dechelotte P AU - Urbain MF AU - Campagne D AU - Malpuech G IN - Department of Pediatrics, BP 69,63003 Clermont-Ferrand Cedex; France. TI - Ladd syndrome in five members of a three-generation family and prenatal diagnosis. SO - Genetic Counseling Vol 5(1) (pp 85-91), 1994. AB - We describe five members of a three generation family with lacrimo-auriculo-dento-digital (LADD) syndrome. The circumstances in which the diagnosis was reached and the details of the case reports underline the great variability of expression of this syndrome and show that caution should be taken in genetic counselling. Prenatal ultrasound should be offered to families at risk so that severe forms of the syndrome, in which termination of pregnancy can be considered, are early detected. <34> UI - 1994103280 AU - Jurek GH AU - Reid WH IN - TXMHMR, PO Box 12668,Austin, TX 78711; United States. TI - Oral health of institutionalized individuals with mental retardation. SO - American Journal on Mental Retardation Vol 98(5) (pp 656-660), 1994. AB - A random 10% (n = 702) of the residents of the Texas Department of Mental Health and Mental Retardation (TXMHMR) institutions were given dental examinations by the first author. Findings were compared with results from a similar survey of 1,077 residents by the same investigator 9 years earlier. Data were analyzed for oral pathology, unmet dental needs, contribution of dental care to habilitation, and effectiveness of the dental service system. Some improvements were found in dental condition, although the results were sometimes difficult to interpret. Some differences may be related to changes in client age and average length of stay and to a shift toward institutionalization of individuals with more severe disabilities. Other differences appear to be the result of better dental care in state institutions. <35> UI - 1994089121 AU - MacDougall M AU - Yen S AU - Crall M AU - Slavkin H AU - Zeichner-David M IN - Ctr Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar St,Los Anqeles, CA 90033; United States. TI - Presence of dentin phosphoprotein in molars of a patient with dentinogenesis imperfecta type II. SO - Journal of Craniofacial Genetics & Developmental Biology Vol 14(1) (pp 26-32), 1994. AB - Dentin phosphoprotein (DPP) is the major noncollagenous protein component of the dentin extracellular matrix. This highly acidic phosphorylated protein is solely expressed by the ectomesenchymal-derived odontoblast cells of the tooth organ. Several biochemical studies have suggested diminished levels of, or even the absence of, this protein, which is associated with the human genetic disease dentinogenesis imperfecta (DGI) type II. However, more recent molecular studies have established that the DPP gene locus is not localized to the region of human chromosome 4 (4q13-q21), where several previous linkage analysis studies have mapped DGI types II and III. The purpose of this study was to determine the presence or absence of DPP in the dentition of a patient affected with DGI type II using a sensitive and specific immunodetection method with a polyclonal antibody against mouse DPP. Our results indicate that a 95-kDa protein, immunologically crossreactive with the DPP antibody, was detected within the dentin extracellular matrix of molars isolated from both a proband affected with DGI-II and from an age-matched normal individual. In addition, both DGI-II and normal individuals showed comparable DPP in situ degradation associated with dentin extracellular matrix maturation. These results strongly support the hypothesis that the DPP structural gene does not produce the gene product primarily responsible for the human genetic disease DGI type II. <36> UI - 1994075096 AU - Wrangsjo K AU - Osterman K AU - Van Hage-Hausten M IN - Dept. Occupational Dermatology, Karolinska Hospital,S-104 01 Stockholm; Sweden. TI - Glove-related skin symptoms among operating theatre and dental care unit personnel (I). Interview investigation. SO - Contact Dermatitis Vol 30(2) (pp 102-107), 1994. AB - 233 employees in hospital and dental care participated in an interview investigation on glove-related skin complaints. 37% (87/233) reported skin symptoms related to glove use. 2% (4/233) reported localized contact urticaria provoked by latex gloves, 10% (23/233) hand eczema and 24% (56/233) unclassifiable skin intolerance reactions from gloves. Another 2% (4/233) reported facial irritation from gloves. Glove-related skin symptoms were thus reported by more than 1/3 of the personnel and the reported glove-provoked contact urticaria constituted 5% (4/87) of the intolerance reactions. <37> UI - 1994057766 AU - Hashida T AU - Uchiyama Y AU - Murakami S IN - Dept. Oral/Maxillofacial Radiology, Osaka University, Faculty of Dentistry, 1-8 Yamadaoka,Suita, Osaka 565; Japan. TI - Dentigerous cyst of an impacted mesiodens. SO - Oral Radiology Vol 9(2) (pp 47-49), 1993. <38> UI - 1994056503 AU - Olsson T AU - Thureson P AU - Borrman H IN - Hospital Dental Care, Vasa Hospital,S-411 33 Goteborg; Sweden. TI - Denture making: A study of temperature resistance of different metal bands for ID-marking. SO - Journal of Forensic Odonto-Stomatology Vol 11(2) (pp 37-44), 1993. AB - Dentures are not always marked. In Sweden legislation now exists to enforce it. This study was undertaken to establish the frequency of marked dentures, the incidence of edentulousness and a temperature resistance test of three possible marking bands. Patients from two long-term units were included in the study (n = 58). Observation of the dental status included absence of teeth, some teeth present and influence of dentures, complete, partial, upper or lower. Marking of the dentures was also recorded. Three different types of steel bands (Jasch; Remanit; ID-band) were exposed to temperature levels of 1100, 1200 and 1300 [degree] C. Of a total of 58 patients 64% were edentulous and only 17 of the patients could be identified by means of the denture markings. None of the metal bands had readable markings at 1200 and 1300 [degree] C, but at 1100 [degree] C the ID-band and the Jasch band were readable, but not the Remanit band. <39> UI - 1994048991 AU - Cox TM IN - Department of Medicine, University of Cambridge, Addenbrooke's Hospital,Cambridge CB2 2QQ; United Kingdom. TI - Aldolase B and fructose intolerance. SO - FASEB Journal Vol 8(1) (pp 62-71), 1994. AB - Hereditary fructose intolerance is an autosomal recessive disorder that illustrates vividly the interplay between heredity and environment in the genesis of human nutritional disease. Genetically determined defects of an isozyme of fructose bisphosphate aldolase (aldolase B, which is specialized for the metabolic assimilation of dietary sugars) predispose to this widely distributed condition. Ingestion of fructose, sorbitol, or sucrose induces abdominal pain, vomiting, and metabolic disturbances - including low concentrations of blood glucose - that may prove fatal. The response to dietary exclusion is rapid and, when so treated, the disease is compatible with a normal life span. A noteworthy feature of the condition in individuals who survive the stormy period of weaning is the development of powerful aversions to fruit, nuts, and sweet-tasting foods and drinks. The incidence of dental caries is consequently much reduced. <40> UI - 1994043765 AU - Goldstein DJ AU - Brunelle RL AU - George RE AU - Cooper SA AU - Desjardins PJ AU - Gaston GW AU - Jeffers GE AU - Gallegos LT AU - Reynolds DC IN - Eli Lilly and Company, Lilly Corporate Center,Indianapolis, IN 46285; United States. TI - Picenadol in a large multicenter dental pain study. SO - Pharmacotherapy Vol 14(1) (pp 54-59), 1994. AB - Study Objective. To estimate the analgesic dose of picenadol hydrochloride equal to codeine 60 mg in a dental pain model. Design. Randomized, double- blind, parallel, dose-response study. Setting. Four university-based dental clinics. Patients. Four hundred eight adult patients with moderate or severe pain after extraction of one or more impacted molar teeth plus bone removal. Interventions. Patients received orally administered single doses of picenadol 15 and 30 mg, codeine phosphate 30 and 90 mg, or placebo. Methods. Single oral doses of picenadol 15 and 30 mg, an opioid agonist-antagonist, were compared with codeine 30 and 90 mg and placebo in 408 patients with moderate or severe pain from third molar extraction in a randomized, double- blind, parallel study. Assessments were performed for pain intensity, pain relief, and adverse events for up to 6 hours after drug administration. Main Results. Picenadol 30 mg and codeine 90 mg were more effective than placebo based on sum of pain intensity differences, total pain relief, peak pain relief, and duration of analgesia (p<0.05). Compared with placebo, the frequency of adverse events was highest for patients receiving codeine 90 mg (p<0.05). No patients discontinued due to adverse events, and all such events resolved spontaneously. Conclusions. Picenadol 22 mg was estimated to be equianalgesic to codeine 60 mg, and picenadol 30 mg was safe in this dental pain model. <41> UI - 1994020379 AU - Bryan DC AU - Hunt NP AU - Pospisil OA IN - Dept of Orthodontics, Queen Elizabeth Military Hospital, Stadium Road,London SE18 4QH; United Kingdom. TI - Surgical accuracy in orthognathic surgery. SO - British Journal of Oral & Maxillofacial Surgery Vol 31(6) (pp 343-350), 1993. AB - This study investigated the accuracy with which the planned surgical change could be achieved during orthognathic surgery, based upon the retrospective cephalometric analysis of 62 patients who received correction of dentofacial deformity. It is concluded that, despite individual variation, no statistically significant difference could be demonstrated between the orthognathic prediction and the surgical outcome. This supports both the use of orthognathic profile planning and the surgeon's ability to follow the plan. <42> UI - 1993357003 AU - Honda M AU - Natsume N AU - Masuda H AU - Kawai T IN - SDOMS, School of Dentistry, Aichi-Gakuin University, 2-11, Suemori-dori,Chikusa-ku, Nagoya 464; Japan. TI - An observation of the dental anlage based on findings in cleft lip patients [15]. SO - Plastic & Reconstructive Surgery Vol 92(7) (pp 1419-1420), 1993. <43> UI - 1993340195 AU - Wright JT AU - Fine J-D AU - Johnson LB AU - Steinmetz TT IN - Department of Pediatric Dentistry, School of Dentistry, University of North Carolina,Chapel Hill, NC 27599; United States. TI - Oral involvement of recessive dystrophic epidermolysis bullosa inversa. SO - American Journal of Medical Genetics Vol 47(8) (pp 1184-1188), 1993. AB - The inversa subtype of autosomal recessive dystrophic epidermolysis bullosa (EBDR-I) is a rare variant characterized by lesions involving primarily the flexural areas of the body. The purpose of this investigation was to characterize the oral manifestations of this unusual dermatologic condition. Ten individuals having EBDR-I were evaluated and compared with an age and sex-matched population of unaffected individuals that served as controls. The diagnosis of EBDR-I was confirmed by skin biopsy that demonstrated tissue separation below the lamina densa and the clinical presentation of blister formation that typically localized to flexural areas. There was clinical variability in the severity and distribution of skin involvement; however, none of the affected individuals demonstrated pronounced digital webbing, severe generalized blistering or growth retardation characteristic of the Hallopeau-Siemens form of EBDR. Oral involvement was seen in all cases with ankyloglossia, loss of tongue papillae and obliteration of the oral vestibule between the lips and gingiva being typical. The oral opening was significantly reduced in older EBDR-I individuals compared with matched controls, confirming that acquired microstomia is a characteristic of EBDR-I. The teeth were not clinically abnormal or malformed and showed no evidence of generalized enamel hypoplasia. Despite this, the prevalence of dental caries in EBDR-I individuals was significantly higher than the control group. The inversa form of EBDR presents with oral findings that are similar but generally milder than those seen in the Hallopeau-Siemens variant of EBDR. <44> UI - 1993335311 AU - Handley J AU - Walsh M AU - Carson D AU - Burrows D AU - Nevin N IN - Department of Dermatology, Royal Belfast Sick Children Hospital, Belfast City Hospital,Belfast; United Kingdom. TI - Laryngo-onycho-cutaneous syndrome associated with familial benign hypercalcemia. SO - Journal of the American Academy of Dermatology Vol 29(5 II) (pp 906-909), 1993. AB - A Pakistani boy had chronic ulceration of the cheeks, generalized nail dystrophy, ulceration and hypergranulation of the nail beds, conjunctiva, and vocal cords, and dental enamel hypoplasia. These features are consistent with laryngo-onycho-cutaneous (LOCS) syndrome or Laryngeal and Ocular Granulation tissue in children from the Indian subContinent (LOGIC) syndrome. Both he and his elder brother had elevated levels of serum calcium consistent with familial benign hypercalcemia. Laryngo-onycho-cutaneous syndrome is a newly recognized condition and its association with familial benign hypercalcemia has not been previously reported. <45> UI - 1993325084 AU - Abidoye RO AU - Oyediran MA AU - Otuyemi IN - Department of Community Health, Lagos University College of Medicine, P.M.B. 12003,Lagos; Nigeria. TI - Dietary habits and dental assessment of suburban and rural children in Nigeria. SO - Nutrition Research Vol 13(11) (pp 1227-1237), 1993. AB - A survey was carried out of 12-year old primary school children in the suburban and rural communities of Ile-Ife and Imesi-Ile respectively to determine their dietary practice and also assess their dental status. The samples consisted of 574 children enrolled in 14 primary schools. These children were examined for dental caries, periodontal diseases, oral hygiene status, dento-facial anomalies and traumatic dental injuries. There was a significant difference in the social background of the children in the communities (P<0.05). The results also showed marked differences in the children's dietary attitude and practice. The caries' prevalence was generally low in the two regions but much lower in the Imesi-Ile sample than in the Ile-Ife sample, with mean DMF scores of 0.05 and 0.39 respectively. Only about 20% of the children of the suburban communities visited dentists compared with 6.6% of those in the rural community. The oral hygiene status was poorer in the Imesi-Ile children than their Ile-Ife counterparts with mean scores of 1.61 and 0.95 respectively. Malocclusion and traumatic dental injuries also showed a lower prevalence in the rural community. In order to meet the WHO standard of retention throughout life of a functional, aesthetic, natural dentition of not less than 20 teeth, and not requiring recourse to a prosthesis, dental health programmes should be intensified to reduce dental problems in rural Nigeria communities because most dental diseases are preventable. <46> UI - 1993319997 AU - Glinsmann WH AU - Bowman BA IN - Dis. Prevention/Hlth. Promo. Office, US Dept. of Health/Human Services,Washington, DC; United States. TI - The public health significance of dietary fructose. SO - American Journal of Clinical Nutrition Vol 58(5 SUPPL.) (pp 820S-823S), 1993. AB - It is increasingly appreciated that some foods and food components, including fructose, have specific health benefits and/or potential risks. This recognition is associated with varied health claims and cautionary statements that can drive dynamic changes in food manufacture, selection, consumption, and views about food safety. It is imperative that the scientific and public health communities develop clear standards for evaluating potential benefits and risks, a process for accurately conveying sound public health information to consumers, and a mechanism for monitoring future changes in the food supply and relating these changes to potential health effects. In this paper we discuss specific and general considerations about the health effects of dietary fructose and provide a perspective on their public health significance. On the basis of currently available information, there is little basis for recommending increased or decreased use of fructose in the general food supply or in products for special dietary use. <47> UI - 1993318024 AU - Silengo M AU - Lerone M AU - Romeo G AU - Calcagno E AU - Martucciello G AU - Jasonni V IN - Istituto di Discipline Pediatriche, Universita di Torino, Piazza Polonia 94,10134 Torino; Italy. TI - Uncombable hair, retinal pigmentary dystrophy, dental anomalies, and brachydactyly: Report of a new patient with additional findings. SO - American Journal of Medical Genetics Vol 47(6) (pp 931-933), 1993. AB - A new ectodermal dysplasia syndrome was reported by Bork et al. in 1987 (Hautarzt 38:342-347). The syndrome consisted of hypotrichosis with the typical SEM (scanning electron microscopy) changes of uncombable hair, retinal pigmentary dystrophy, juvenile cataract, oligodontia, brachydactyly with brachymetacarpia; it was inherited as an autosomal dominant trait. We describe a sporadic case and add further clinical findings to expand the spectrum of this rare syndrome. <48> UI - 1993318018 AU - Maat-Kievit A AU - Brunner HG AU - Maaswinkel-Mooij P IN - Department of Clinical Genetics, University Hospital, Postbox 9600,2300 RC Leiden; Netherlands. TI - Two additional cases of the Ohdo blepharophimosis syndrome. SO - American Journal of Medical Genetics Vol 47(6) (pp 901-906), 1993. AB - Two additional cases of the Ohdo blepharophimosis syndrome are described and compared to the 5 patients previously reported. Blepharophimosis, ptosis, dental hypoplasia, mental retardation, and deafness can be considered as common manifestations of the syndrome. Male patients show cryptorchidism and scrotal hypoplasia. <49> UI - 1993311317 AU - Singleton RJ AU - Ludbrook GL AU - Webb RK AU - Fox MAL IN - Australian Patient Safety Foundation, GPO Box 400,Adelaide, SA 5001; Australia. TI - Physical injuries and environmental safety in anaesthesia: An analysis of 2000 incident reports. SO - Anaesthesia & Intensive Care Vol 21(5) (pp 659-663), 1993. AB - Of the first 2000 incidents reported to the Australian Incident Monitoring Study, 56 (3%) involved environmental hazards or injuries to patients or staff. There were 17 cases of oral trauma (14 of tooth loss or damage, in 7 of which poor dentition played a role), 10 incidents involving problems with the operating table, 6 cases of skin or eye damage and 6 cases in which an electrical hazard was identified. Five incidents occurred during transport, and there were 4 cases of monitor induced trauma, 4 'needlestick' injuries and 4 miscellaneous incidents. Recommendations are made for trying to avoid or reduce the incidence of some of these problems. <50> UI - 1993298259 AU - Fox PC IN - Clinical Investigations Section, Clin Investigat Patient Care Branch, Nat Inst Dental Res, Nat Inst Hlth,Bethesda, MD 20892; United States. TI - Salivary monitoring in oral diseases. SO - Annals of the New York Academy of Sciences Vol 694 (pp 234-237), 1993. <51> UI - 1993292004 AU - Hennekam RCM AU - Holtus FJAM IN - Institute of Human Genetics, Academic Medical Hospital, Meibergdreef 15,1105 AZ Amsterdam; Netherlands. TI - Johnson-McMillin syndrome: Report of another family. SO - American Journal of Medical Genetics Vol 47(5) (pp 714-716), 1993. AB - We describe a mother and son with facial nerve palsy, multiple truncal cafe-au-lait spots, and mild developmental delay. The mother also had hyposmia, increased tendency to caries, and growth retardation, and the son hypotrichosis, hearing loss, and microtia. This apparently autosomal dominant disorder was described first by Johnson et al. [1983: Am J Med Genet 15:497- 506] and Johnston et al. [1987: Am J Med Genet 26:925-927]. <52> UI - 1993288404 AU - Brook U AU - Katzir Z IN - Pediatric Department, Wolfson Medical Center,Holon; Israel. TI - Health problems of adolescents in Holon, Israel. SO - International Journal of Adolescent Medicine & Health Vol 6(1) (pp 13-20), 1993. <53> UI - 1993288160 AU - Yell JA AU - Marren PM IN - Department of Dermatology, Churchill Hospital,Oxford OX3 7LJ; United Kingdom. TI - Skin changes in epilepsy. SO - Journal of the European Academy of Dermatology & Venereology Vol 2(3) (pp 217-224), 1993. AB - Aims: To establish the skin changes found in epileptics, and to relate these changes to drug therapy. Background: Skin changes in epileptics, although well acknowledged, have been subjected to few recent large-scale surveys. Newer anti-epileptic drugs, in addition to the older therapies, including phenytoin, phenobarbitone and primidone, are now popular. In an effort to update our knowledge of skin changes in epileptics, a study of 200 patients in a long-term epilepsy hospital was performed. Methods: The study included taking a history, recording drug therapy and examining the skin of 200 patients. Results: Patients ranged in age from 21 to over 70. 60% were men and 40% women. Their epilepsy was mostly well controlled, varying in length from less than 10 to greater than 40 years. 57.5% had post traumatic scars. 32.5% had gum hypertrophy, only half having dental caries. Dupuytren's contracture occurred in 24.5%. Seborrheic dermatitis was seen in 15%. 12.5% had coarse facial features and 11.5% had acne. 57.5% of women had facial hirsutes. 17.5% of all patients had sacral hirsutes, which is an unique feature in this group of patients. These clinical findings were correlated with drugs taken at the time, the age of the patients and length of epilepsy. 52% were on carbamazepine, 48% on phenytoin and 42% on primidone or phenobarbitone, singly or in combination. Conclusions: A number of skin conditions are more common among epileptics. Phenytoin and phenobarbitone are linked to gingival hypertrophy, palmar fibromatosis, hypertrichosis, coarse facies and acne. Carbamazepine, too, may be implicated in gum hypertrophy, palmar fibromatosis, hypertrichosis, more specifically sacral hirsutes, seborrheic dermatitis, acne and coarse facies. <54> UI - 1993285497 AU - Iraci S AU - Bianchi L AU - Gatti S AU - Carrozzo AM AU - Bettini D AU - Nini G IN - Department of Dermatology, Tor Vergata University, Ospedale S. Eugenio, P.le dell'Umanesimo 10,00144 Rome; Italy. TI - Pachyonychia congenita with late onset of nail dystrophy - A new clinical entity?. SO - Clinical & Experimental Dermatology Vol 18(5) (pp 478-480), 1993. AB - Pachyonychia congenita syndrome (PCS) is a genetic disease with an autosomal dominant mode of transmission in which the main sign, pachyonychia, usually arises at birth or in childhood together with other disorders of keratinization. A 28-year-old woman developed subungual hyperkeratosis of all toe-nails and thumb-nails associated with pain on pressure and walking. She had a scrotal tongue with leucokeratotic areas, blister formation, plantar hyperkeratosis, palmoplantar hyperhidrosis and dental cavities since childhood. The present case, interpreted as PCS of late onset, could be a clinical variant of the Jadassohn-Lewandowsky syndrome with the late onset of pachyonychia or else an additional form of PCS due to the expression of a new and different allele. <55> UI - 1993277874 AU - Oikarinen K AU - Ignatius E AU - Silvennoinen U IN - Institute of Dentistry, University of Oulu, Aapistie 3,90220 Oulu; Finland. TI - Treatment of mandibular fractures in the 1980s. SO - Journal of Cranio-Maxillo-Facial Surgery Vol 21(6) (pp 245-250), 1993. AB - Treatment of 317 mandibular fracture patients between 1981 and 1990 at the Department of Oral and Maxillofacial Surgery, Institute of Dentistry, University of Oulu and Oulu University Hospital were analysed on the basis of patient files and radiographs. The patients had suffered altogether 452 mandibular fractures, most in the condylar region. The treatment was operative in 24% of cases and conservative in 76%. Operative treatment was commoner in edentulous than in partially edentulous or dentate patients. The proportion of operatively treated mandibular fractures increased toward the end of the period. The type of osteosynthesis also changed over the decade as wire and plate osteosynthesis gave way to compression plating and then to titanium miniplate and screw fixation of fractures. The advantages and disadvantages of the treatment methods are discussed and some typical cases using various modern fixation techniques are presented. <56> UI - 1993275693 AU - Sasaki J AU - Yamane N AU - Takai H AU - Ikeshima K AU - Oone M AU - Hara H AU - Shiiki K AU - Kanno K AU - Sakamoto H AU - Kaneko A AU - Satoh T AU - Uchikawa Y AU - Michi K-I AU - Wakumoto M AU - Ishibashi K AU - Yamamoto H AU - Yamamoto E AU - Nakagawa K AU - Konnai T AU - et al IN - Department of Oral Surgery, School of Medicine, Tokai University, Boseidai,Isehara 259-11; Japan. TI - Fundamental and clinical studies on S-1108 in oral surgery. SO - Chemotherapy Vol 41(SUPPL. 1) (pp 718-734), 1993. <57> UI - 1993263599 AU - Bringhurst C AU - Herr RD AU - Aldous JA IN - Division of Emergency Medicine, Department of Surgery, University of Utah Medical Center, 50 N Medical Dr,Salt Lake City, UT 84132; United States. TI - Oral trauma in the emergency department. SO - American Journal of Emergency Medicine Vol 11(5) (pp 486-490), 1993. AB - Oral trauma is commonly observed in the emergency department, and the emergency physician has the opportunity to greatly improve prognosis for these types of injuries through prompt and appropriate initial management. Injuries resulting from oral trauma can be physically and psychologically devastating to patients, and initial treatment must often be accomplished before dental consultation is available. This article provides the emergency physician with guidelines for diagnosis, initial management, and referral for oral injuries. <58> UI - 1993262605 AU - Jasmin JR AU - Jonesco-Benaiche N AU - Muller-Giamarchi M IN - UFR d'Odontologie, Parc Valrose, Avenue Joseph Vallot,060108 Nice Cedex; France. TI - Supernumerary teeth in twins. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 76(2) (pp 258-259), 1993. <59> UI - 1993262046 AU - Jette AM AU - Feldman HA AU - Tennstedt SL IN - New England Research Institute, Inc, 9 Galen St,Watertown, MA 02172; United States. TI - Tobacco use: A modifiable risk factor for dental disease among the elderly. SO - American Journal of Public Health Vol 83(9) (pp 1271-1276), 1993. AB - Objectives. Because the public health literature contains few analytic studies of modifiable behavioral risk factors for dental disease among older community-dwelling populations, the New England Elders Dental Study was undertaken as an epidemiologic study of the oral health status of a representative sample of older adults living within the six New England states. Methods. Five dentists conducted comprehensive in-home oral health examinations on 1156 community-dwelling adults aged 70 and older to determine whether lifetime use of tobacco products was a significant risk factor for tooth loss, caries, and periodontal disease. Results. Among New England elders, tobacco use was more common among men (18.1%) than women (7.9%), with a combined rate of 12.3%. Further, 64.7% of men and 36.6% of women were previous tobacco users. Years of exposure to tobacco products was a statistically significant risk factor for tooth loss, coronal and root caries, and periodontal disease, regardless of other social and behavioral factors. Conclusions. Lifelong tobacco use is a modifiable risk factor for poor dental health among older adults. Dental practitioners need to intervene with all their adult patients to discourage use of tobacco products for oral as well as general preventive health care. <60> UI - 1993247929 AU - Schepers E AU - De Clercq M AU - Ducheyne P IN - Department of Prosthetic Dentistry, Catholic University of Leuven, Capucijnenvoer 7,3000 Leuven; Belgium. TI - Interfacial tissue response to bioactive glasses with reduced surface reactivity. SO - Journal of Materials Science-Materials in Medicine Vol 4(3) (pp 300-304), 1993. <61> UI - 1993246135 AU - Lehmann AR AU - Thompson AF AU - Harcourt SA AU - Stefanini M AU - Norris PG IN - MRC Cell Mutation Unit, University of Sussex,Falmer, Brighton BN1 9RR; United Kingdom. TI - Cockayne's syndrome: Correlation of clinical features with cellular sensitivity of RNA synthesis to UV irradiation. SO - Journal of Medical Genetics Vol 30(8) (pp 679-682), 1993. AB - Cockayne's syndrome (CS) is a rare autosomal recessive disorder with dwarfism, mental retardation, and otherwise clinically heterogeneous features. In cultured CS fibroblasts, the failure of RNA synthesis to recover to normal rates after UV-C irradiation provides a useful and relatively simple diagnostic test. We have measured post-UV-C RNA synthesis in 52 patients for whom a clinical diagnosis of CS was considered a possibility. Twenty-nine patients showed the defect characteristic of CS cells, and 23 had a normal response. We have attempted to correlate the cellular diagnosis with the different clinical features of the disorder. Clinical details of the patients were obtained from referring clinicians in the form of a questionnaire. Our results show that, apart from the cardinal features of dwarfism and mental retardation, sun sensitivity correlated best with a positive cellular diagnosis. Pigmentary retinopathy, gait defects, and dental caries were also good positive indicators, although several patients with a positive cellular diagnosis did not have these features. <62> UI - 1993241224 AU - Gaspersic D IN - Faculty of Medicine, Department of Stomatology, Hrvatski trg 6,61000 Ljubljana; Slovenia. TI - Morphology of the most common form of protostylid on human lower molars. SO - Journal of Anatomy Vol 182(3) (pp 429-431), 1993. AB - Scanning electron microscopy of the enamel surface and enamel structure in the protostylid area classified as a surface irregularity was performed on 26 human lower third molars. This protostylid class can be regarded as the onset of a cusp formation, while the protostylid pits should be considered to be fissures between a protoconid and a poorly expressed protostylid. <63> UI - 1993240714 AU - Lustmann J AU - Nahlieli O AU - Harary D AU - Casap N AU - Neder A AU - Zlotogora J IN - Dept. of Oral/Maxillofacial Surgery, Hadassah School of Dental Medicine, P.O. Box 1172,Jerusalem; Israel. TI - Gerodermia Osteodysplastica: Report on two patients and surgical correction of facial deformity. SO - American Journal of Medical Genetics Vol 47(2) (pp 261-267), 1993. AB - We present four individuals with Gerodermia Osteodysplastica in a Jewish family from Morocco confirming the autosomal recessive inheritance of the disorder. Three previously unreported findings are described: a) enlarged funnel-shaped mandibular lingula; b) extension of the mandibular premolar and molar roots below the inferior dental canal, and of the second molars into the lower border of mandibular cortical bone; and c) hypercementosis of the maxillary incisors and mandibular molars surrounded by a radiolucent halo in several teeth. The facial deformity resulting from maxillary hypoplasia and mandibular prognathism was corrected by orthognathic surgery: Le Fort I maxillary osteotomy and vertical mandibular osteotomy. <64> UI - 1993239333 AU - Yalcin S AU - Gurbuzer B IN - Haydarpasa Training Hospital, Gulhane Military Medical Academy,Istanbul; Turkey. TI - Multiple impacted teeth in the maxilla. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 76(1) (pp 130), 1993. <65> UI - 1993239331 AU - Patel JR IN - Department of Diagnostic Sciences, University of Alabama, School of Dentistry,Birmingham, AL; United States. TI - Transposition and microdontia. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 76(1) (pp 129), 1993. <66> UI - 1993232721 AU - Waaler SM AU - Rolla G AU - Skjorland KK AU - Ogaard B IN - Dept of Preclinical Techniques/, Material Sciences, Dental Faculty, University of Oslo, Geitmyrsveien 69,0455 Oslo; Norway. TI - Effects of oral rinsing with triclosan and sodium lauryl sulfate on dental plaque formation: A pilot study. SO - Scandinavian Journal of Dental Research Vol 101(4) (pp 192-195), 1993. <67> UI - 1993226427 AU - Andrews JM AU - Martins DMF AU - Ramos RR AU - Ferreira LM IN - Division of Plastic Surgery, Escola Paulista de Medicina, Rua Napoleao de Barros 715-4andar,Sao Paulo 04024; Brazil. TI - A severe case of Beare-Stevenson syndrome and associated congenital deformities. SO - British Journal of Plastic Surgery Vol 46(5) (pp 443-446), 1993. AB - A severe case of congenital anomalies is described, with several characteristics of Beare-Stevenson syndrome, such as cutis gyrata, acanthosis nigricans, craniofacial anomalies, ear defects, enlarged umbilical stump and anogenital anomalies. He does not have craniosynostosis or clover leaf skull, which has also been described in this syndrome. This patient also shows hands and feet anomalies, absence of skin adnexa in several locations and dental anomalies, which could suggest an associated ectodermal dysplasia. <68> UI - 1993212146 AU - Seow WK IN - University of Queensland, Dental School, Turbot Sr,Brisbane, QLD 4000; Australia. TI - Taurodontism of the mandibular first permanent molar distinguishes between the tricho-dento-osseous (TDO) syndrome and amelogenesis imperfecta. SO - Clinical Genetics Vol 43(5) (pp 240-246), 1993. AB - The diagnosis of tricho-dento-osseous (TDO) syndrome is often confused with that of a variant of amelogenesis imperfecta (AI) which shows similar dental features of hypomaturation-hypoplastic enamel defects and putative taurodontism. In this controlled study, an objective, biometric measurement technique was used to determine the prevalence and severity of taurodontism of the mandibular first permanent molar in 23 patients with AI and one patient with TDO syndrome compared with age- and sex-matched controls. The published radiographs of previous cases of TDO and hypomaturation-hypoplastic AI were also reviewed with regard to the presence and severity of taurodontism. The results indicate that in all cases of TDO, taurodontism of the molars including mandibular first permanent molars was consistently present and in a severe form. By contrast, the taurodontic defects present in all cases of AI, including the hypomaturation-hypoplastic variant were not significantly different from matched, healthy controls. Of significance is the fact that in all the AI cases, none of the taurodontic defects were present on the mandibular first permanent molars. The results indicate that true taurodontism as indicated by a change in the mandibular first permanent molars occurs only in the TDO syndrome. This feature may be used to differentiate clearly between TDO and AI. <69> UI - 1993207635 AU - Lund TW AU - Wade M IN - Dentistry Department, Hennepin County Medical Center, 701 Park Avenue,Minneapolis, MN 55415; United States. TI - Use of osseointegrated implants to support a maxillary denture for a patient with repaired cleft lip and palate. SO - Cleft Palate-Craniofacial Journal Vol 30(4) (pp 418-420), 1993. AB - Although many cleft lip and palate patients retain their dentition, some develop partial or complete edentulism. The configuration of the residual maxillary alveloar ridge may provide little support for a complete or partial maxillary denture. The success of the Branemark dental implant has been well established, and although placement of implants in the maxilla may present a surgical challenge, implants are very effective in providing support and, therefore, retention and stability. Application of implants to the cleft palate maxilla is particularly valuable because of the difficulty in constructing well-fitting conventional dentures for CLP patients, and the relatively compromised nature of the prostheses when made. This report presents the prosthetic treatment of a nearly edentulous cleft lip and palate patient. <70> UI - 1993197001 AU - Camarasa JG AU - Serra-Baldrich E AU - Lluch M AU - Malet A IN - Allergo Centre, Josep Tarradellas 152,08029 Barcelona; Spain. TI - Contact urticaria from sodium fluoride. SO - Contact Dermatitis Vol 28(5) (pp 294), 1993. <71> UI - 1993184743 AU - Moghadam BKH AU - Zadeh JY AU - Gier RE IN - Dept. of Oral Diagnosis/Radiology, School of Dentistry, University of Missouri, 650 East 25th Street,Kansas City, MO 64108; United States. TI - Ataxia-telangiectasia: Review of the literature and a case report. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 75(6) (pp 791-797), 1993. <72> UI - 1993184742 AU - Wisnom CJ AU - Kelly M IN - Department of Oral Medicine, Baltimore College of Dental Surgery, Maryland Univ.-Baltimore Dental Sch., 666 W. Baltimore Street,Baltimore, MD 21201; United States. TI - Medical/dental management of a chronic hepatitis C patient: A case report. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 75(6) (pp 786-790), 1993. <73> UI - 1993184721 AU - Terry BC AU - Hegtvedt AK IN - Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina,Chapel Hill, NC 27599-7450; United States. TI - Self-stabilizing approach to surgical uprighting of the mandibular second molar. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 75(6) (pp 674-680), 1993. <74> UI - 1993184720 AU - Smith RA AU - Vargervik K AU - Kearns G AU - Bosch C AU - Koumjian J IN - Dept. of Oral/Maxillofacial Surgery, University of California, Box 0440, 521 Parnassus,San Francisco, CA 94143-0440; United States. TI - Placement of an endosseous implant in a growing child with ectodermal dysplasia. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 75(6) (pp 669-673), 1993. <75> UI - 1993184699 AU - Midda M AU - Renton-Harper P AU - Roberts-Harry D TI - Letter to the editor. SO - Lasers in Surgery & Medicine Vol 13(3) (pp 379-380), 1993. <76> UI - 1993180555 AU - Pfaff JA AU - Geninatti M IN - 2028 Merrimac Drive,Fayetteville, NC 28304; United States. TI - Hemophilia. SO - Emergency Medicine Clinics of North America Vol 11(2) (pp 337-363), 1993. AB - Hemophilia and von Willebrand's disease are the most common hereditary bleeding disorders. A variety of treatment modalities of these disorders are discussed. Common organ system bleeding and its treatment and disposition are outlined. Finally, potential complications of both the disease and treatment are reviewed. <77> UI - 1993160801 AU - Thomas JE AU - Bender BS IN - Geriatric Dental Programs, Department of Veterans Affairs, Veterans Affairs Medical Center, 1601 SW Archer Rd,Gainesville, FL 32608-1197; United States. TI - What to look for after you say 'open wide': A guide to examination of oral cavity. SO - Postgraduate Medicine Vol 93(7) (pp 109-110+113-115), 1993. <78> UI - 1993126799 AU - Kulekci G AU - Bilgin T AU - Egilmez S AU - Turfaner M AU - Ang O IN - Department of Microbiology, Faculty of Dentistry, Istanbul University,34390 Istanbul; Turkey. TI - The presence of black-pigmented Gram-negative anaerobes in the oral cavity of edentulous subjects. SO - FEMS Immunology & Medical Microbiology Vol 6(2-3) (pp 219-222), 1993. AB - The aim of this study was to investigate whether black-pigmented Gram-negative anaerobes are part of the indigenous oral flora of edentulous subjects with or without dentures. Group I consisted of 11 subjects with dentures (mean age 63.6 years, range 52-75) and Group II consisted of 39 subjects with complete dentures in both jaws (mean age 59.3 years, range 37-80). Two microbial samples for microbiological examination were taken from each subject. One of them was from the dorsum of the tongue and the other was from saliva. Black-pigmented Gram-negative anaerobes > 107 cfu/ml were found in both samples. In 50 edentulous subjects, they were found more commonly from tongue (40%) than from saliva (26%). None of the subjects had Porphyromonas gingivalis. There was no statistically significant difference (P > 0.05) between the presence of black-pigmented Gram-negative anaerobes on tongue and in saliva in the two groups. Our results suggested that high levels of black-pigmented Gram-negative anaerobes may belong to the indigenous oral flora in edentulous mouths with or without dentures. <79> UI - 1993123607 AU - Llamas R AU - Jimenez-Planas A IN - Avda. de las Villas de Cuba, 29,41007-Sevilla; Spain. TI - Taurodontism in premolars. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 75(4) (pp 501-505), 1993. <80> UI - 1993122766 AU - Isaksson M AU - Bruze M AU - Bjorkner B AU - Niklasson B IN - Department of Dermatology, General Hospital,S-214 01 Malmo; Sweden. TI - Contact allergy to Duraphat. SO - Scandinavian Journal of Dental Research Vol 101(1) (pp 49-51), 1993. <81> UI - 1993120721 AU - Kumar A AU - Rawlings RD AU - Beaman DC IN - Dept of Pediatrics/Human Development, B240 Life Sciences Bldg, Michigan State University,East Lansing, MI 48824-1317; United States. TI - The mystery ingredients: Sweeteners, flavorings, dyes, and preservatives in analgesic/antipyretic, antihistamine/decongestant, cough and cold, antidiarrheal, and liquid theophylline preparations. SO - Pediatrics Vol 91(5 I) (pp 927-933), 1993. AB - Objective. Pharmaceutical preparations may contain a variety of excipients ('inert ingredients'). These excipients are generally inactive; however, rare adverse effects caused by excipients have been reported. Information about the excipients in a particular preparation is not readily available. Methods. The information about sweeteners, flavorings, dyes, and preservatives for the chewable and liquid preparations of over-the-counter and prescription products of antidiarrhea, cough and cold, antihistamine/decongestant, analgesic/antipyretic, and liquid theophylline medications was collected. Results. Information about excipients in 102 chewable and liquid preparations was compiled. An average preparation contained two sweeteners. Saccharin and sucrose were the most common sweeteners found-each was present in 52 preparations-followed by sorbitol, glucose, fructose, and others. For 36 of the 102 preparations, type of flavoring was not specified. In the remaining preparations, cherry was the most common flavoring, followed by vanilla and lemon. Twenty-one different dyes and coloring agents were used. Red dye No. 40 was the most common (42/102), followed by yellow No. 6 (27/102). Of the eight preservatives used, sodium benzoate and methylparabens were present in 42 and 27 of the preparations, respectively. Tables detailing these excipients and adverse effects reported are presented. Conclusions. The tables should be helpful to physicians in selecting preparations containing different excipients when an adverse reaction occurs. The mandatory labeling of excipients in all pharmaceutical preparations is the only way that physicians and patients can be fully informed. <82> UI - 1993112907 AU - Tindlund RS AU - Rygh P AU - Boe OE IN - Dept Orthodontics/Facial Orthopedics, School of Dentistry, University of Bergen, Arstadvn 17,N-5009 Bergen; Norway. TI - Intercanine widening and sagittal effect of maxillary transverse expansion in patients with cleft lip and palate during the deciduous and mixed dentitions. SO - Cleft Palate-Craniofacial Journal Vol 30(2) (pp 195-207), 1993. AB - Since 1977 cleft lip and palate (CLP) patients with maxillary deficiency have received an interceptive orthopedic treatment consisting of (a) transverse expansion, (b) protraction, and (c) fixed retention. Ideally the treatment should be completed early enough to permit spontaneous eruption of the maxillary permanent incisors into normal occlusion without orthodontic intervention. The early transverse expansion considerably increases space so that unerupted malpositioned incisors spread out spontaneously, creating optimal conditions for eruption and root formation. Dental diagnosis in the cleft areas is made easier. Posterior crossbites in 112 CLP patients were expanded with a modified quad-helix appliance cemented with four bands in the deciduous or mixed dentition. Intercanine widening was about 3 mm per month regardless of cleft type. Several authors have claimed that transverse expansion of the upper jaw will increase sagittal overjet. Other authors have not found such an effect. The sagittal effect on the maxilla was studied in 68 CLP patients who had received transverse expansion. Analysis of the lateral cephalograms revealed no significant sagittal dentofacial maxillary treatment effects involving forward movement of maxilla, but a downward clockwise rotation of the mandible was found. <83> UI - 1993105899 AU - Bircher AJ AU - Lang-Muritano M AU - Pfaltz M AU - Bruckner-Tuderman L IN - Department of Dermatology, University of Basle, Petersgraben 4,CH-4031 Basle; Switzerland. TI - Epidermolysis bullosa junctionalis progressiva in three siblings. SO - British Journal of Dermatology Vol 128(4) (pp 429-435), 1993. AB - Three siblings of Swiss origin with epidermolysis bullosa junctionalis progressiva are described. The following clinical features were present from school age: dystrophy of the nails, non-scarring blistering of the skin, mild skin atrophy, hypodontia and dental caries. Light microscopy showed subepidermal blistering. Direct immunofluorescence was negative. On indirect immunofluorescence staining of a fresh spontaneous bliaster, bullous pemphigoid antigen and laminin were localized to the blister roof, and collagen IV and collagen VII to the blister base, indicating junctional splitting. Electron microscopy revealed a normal dermo-epidermal junction zone, including normal hemidesmosomes. There were no deposits of electron-dense amorphous material. <84> UI - 1993097674 AU - Smith CR IN - Department of Prosthodontics, Univ. of Texas Health Science Center, 7703 Floyd Curl Drive,San Antonio, TX 78284-7912; United States. TI - Osseointegrated dental implants - Another option in clinical dentistry. SO - Mayo Clinic Proceedings Vol 68(4) (pp 402-403), 1993. <85> UI - 1993097660 AU - Tolman DE AU - Laney WR IN - Department of Dentistry, Mayo Clinic,Rochester, MN 55905; United States. TI - Tissue-integrated dental prostheses: The first 78 months of experience at the Mayo Clinic. SO - Mayo Clinic Proceedings Vol 68(4) (pp 323-331), 1993. AB - During a 78-month period at the Mayo Clinic, 1,778 Branemark endosseous dental implants were placed in the edentulous or partially edentulous jaws of 353 consecutive patients who ranged in age from 8 to 82 years. The largest treatment category involved edentulous mandibles, which accounted for 53% of the total restorations. Approximately 76% of the threaded cylindrical implants supported 312 oral prostheses at the end of the study period. The implant survival rate was 97.8% in the mandible and 88.8% in the maxilla. Complications associated with this treatment included loss of implant anchorage in bone, soft tissue problems, and mechanical difficulties related to design and function of the prostheses. All complications were managed without loss of continuous function of the prostheses, except in four patients who resumed wearing a conventional removable maxillary complete denture. This experience demonstrates that Branemark endosseous dental implants are predictable and can provide lasting integration under function when placed and loaded in accordance with the recommended protocol. <86> UI - 1993087622 AU - Saunders SR AU - Fitzgerald WR IN - Department of Archaeology, University of Calgary,Calgary, Alta. T2N 1N4; Canada. TI - Age differences in stable carbon and nitrogen isotope ratios in a population of prehistoric maize horticulturists. SO - American Journal of Physical Anthropology Vol 90(3) (pp 267-281), 1993. AB - Stable carbon isotope ratios in prehistoric human bone collagen have been used extensively to document the introduction and intensification of maize horticulture in northeastern North America. Most previous studies are based on small samples of adults who are assumed to characterize the diet of the population. In this study, all 29 individuals buried within an Ontario Iroquoian village site dated A.D. 1530-1580 were analysed for stable isotopes of carbon and nitrogen. Age distribution of the sample ranges from preterm to elderly. Significant negative correlations between age and delta13C, and age and delta15N values were found. High delta13C values in infants and young children (delta13C = -6.8 to -12.3) suggest a weaning diet high in maize. High delta15N values in infants relative to adults suggest a trophic level effect during breast-feeding which has been reported in a modern sample by Tuross et al. In addition to the isotopic evidence for extremely high carbohydrate (maize) intake, the MacPherson sample includes two juveniles aged 3-4 years, exhibiting circular caries. No other cases of this condition are known in the extensively studied southern Ontario skeletal collections. Together the evidence from dentition and stable carbon isotopes indicates a very high carbohydrate diet in subadults. Circular caries result from developmental stress during enamel formation with subsequent caries formation in areas of thinner enamel. These findings are relevant to studies of infant and early childhood morbidity and mortality among prehistoric maize horticulturists. <87> UI - 1993084169 AU - Douglass CW AU - Jette AM AU - Fox CH AU - Tennstedt SL AU - Joshi A AU - Feldman HA AU - McGuire SM AU - McKinlay JB IN - Dept. of Dental Care Administration, Harvard School of Dental Medicine, 188 Longwood Avenue,Boston, MA 02115; United States. TI - Oral health status of the elderly in New England. SO - Journals of Gerontology Vol 48(2) (pp M39-M46), 1993. AB - The New England Elders Dental Study (NEEDS) reports the prevalence, extent and severity of oral diseases and conditions among a representative sample of community-dwelling elders age 70 and older residing throughout the six New England states. In-home, full-mouth examinations were conducted by four calibrated dentists who used National Institute of Dental Research (NIDR) standardized disease measures plus additional diagnostic codes on all tooth surfaces. Only 37.6% of elders age 70 and older were edentulous, while dentate elders had a mean number of teeth per person ranging from 21.5 to 17.9 across age and gender cohorts. The prevalence of untreated coronal decay in elders with teeth was 28% in female elders and 34% in male elders. More than 90% of all elders with teeth had coronal fillings and 22% exhibited untreated root caries. Periodontal destruction was substantial, with 66% of dentate elders exhibiting moderate periodontal pockets (4-6 mm) while 21% exhibited severe periodontal pocketing (>6 mm). Comparisons with national surveys suggest that periodontal disease prevalence and severity appear to have been underestimated in previous national studies of the elderly. Because of aging and tooth retention trends, the periodontal disease problem of the elderly may be increasing in the face of dentists' tendency to underdiagnose the periodontal diseases, legal constraints on dental hygienists to independently treat them, and inadequate funding for conservative nonsurgical therapies. <88> UI - 1993083882 AU - Uehara S AU - Akai Y AU - Takeyama Y AU - Okamura K AU - Takabayashi T AU - Yajima A AU - Natsui M AU - Nakai H IN - Dept of Obstetrics and Gynecology, Tohoku University School of Medicine, 1-1 Seiryo-machi,Aoba-ku, Sendai, Miyagi 980; Japan. TI - A case of a female infant with simultaneous occurrence of de novo terminal deletions on chromosome 14q and 20p. SO - Clinical Genetics Vol 43(1) (pp 28-33), 1993. AB - This is a case report on an infant with de novo terminal deletions on the long arm of chromosome 14 and on the short arm of chromosome 20 [46, XX, del(14)(q32)del(20)(p11)]. Examination revealed that the infant had a peculiar face, a cleft and high palate, abnormal dentition, butterfly-like vertebral defects, finger anomalies, a simian line on the left hand, talipes equinovarus, deep plantar furrows, abnormally high values of alkali phosphatase and lactate dehydrogenase, mild anemia and psychomotor retardation. Comparing the present case with previously reported cases of a single deletion on chromosome 14q or chromosome 20p, the infant showed some symptomatic and dysmorphic features of both deletions. <89> UI - 1993075035 AU - Dooms-Goossens A AU - Boden G AU - Aupaix F AU - Bruze M IN - Dept Medical Research (Dermatology), University Hospital, Katholieke Universiteit Leuven,Leuven; Belgium. TI - Allergic contact dermatitis from adhesive plaster due to colophony and epoxy resin. SO - Contact Dermatitis Vol 28(2) (pp 120-121), 1993. <90> UI - 1993075032 AU - Castelain M AU - Castelain P-Y IN - Service de Dermatologie, Hopital Sainte-Marguerite,F-13277 Marseille Cedex 9; France. TI - Allergic contact dermatitis from cetyl pyridinium chloride in latex gloves. SO - Contact Dermatitis Vol 28(2) (pp 118), 1993. <91> UI - 1993068830 AU - McDonnell D AU - Esposito M AU - Todd ME IN - Dept Oral Medical Surgical Sciences, Faculty of Dentistry, University of British Columbia, 2199 Wesbrook Mall,Vancouver, BC V6T 1Z3; Canada. TI - A teaching model to illustrate the variation in size and shape of the maxillary sinus. SO - Journal of Anatomy Vol 181(2) (pp 377-380), 1992. AB - A technique to produce teaching models of the maxillary sinus is described. Dental impression material is injected into the maxillary sinus of a cadaver and subsequently dissected out. Using an impression and mould technique in a series of steps, a stone model of the maxillary sinus is produced. The shape, size and configuration of the model can be seen and the dimensions measured. A radiopaque impression material can be used so that the radiographic outline of the maxillary sinus on standard radiographic projections can be shown. Models of both dentate and edentulous patients can be used to show anatomical variation and the relationship to teeth and are useful in teaching both gross and radiographic anatomy. Since 10 out of 11 specimens had 3 walls leading to the apex from a 4-sided base, it would appear that the classical description of a 4-sided pyramidal shape to the maxillary sinus is relatively uncommon. <92> UI - 1993063903 AU - Gadzhiev SA AU - Mamedov MA AU - Starikov NA AU - Teologova EL TI - Application of button spherical fixatives in designing splinting dentures. SO - Biomedical Engineering Vol 26(4) (pp 181-183), 1992. <93> UI - 1993054788 AU - Trott MS AU - Helm TN TI - Clinical and pathologic diagnosis. Pathologic quiz case 1: Pathologic diagnosis: Cicatricial pemphigoid. SO - Archives of Otolaryngology -- Head & Neck Surgery Vol 119(2) (pp 246+248), 1993. <94> UI - 1993049493 AU - Heinz GW AU - Bateman JB AU - Barrett DJ AU - Thangavel M AU - Crandall BF IN - Doris Stein Eye Research Center, Jules Stein Eye Institute, UCLA Medical Center, 200 Stein Plaza,Los Angeles, CA 90024; United States. TI - Ocular manifestations of the lacrimo-auriculo-dento-digital syndrome. SO - American Journal of Ophthalmology Vol 115(2) (pp 243-248), 1993. AB - We studied a mother and daughter with an extremely rare constellation of signs and symptoms. One or both had absent lacrimal puncta, nasolacrimal duct obstruction, chronic dacryocystitis, dry eyes, and epiphora. Systemic findings included salivary gland hyposecretion, dental hypoplasia and dysplasia, cup-shaped ears with hearing loss, and digital anomalies. These findings are consistent with those of the lacrimo-auriculo-dento-digital syndrome, a genetic disorder. Our study supports the autosomal dominant inheritance of this syndrome, delineates the ophthalmic manifestations, and provides evidence that renal anomalies are part of the disorder. <95> UI - 1993047086 AU - Hochberg MS AU - Vazquez-Santiago IA AU - Sher M IN - Dental Department, Interfaith Medical Center, 555 Prospect Place,Brooklyn, NY 11238; United States. TI - Epidermolysis bullosa. A case report. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 75(1) (pp 54-57), 1993. <96> UI - 1993045204 AU - Foltyn P IN - Dental Department, St Vincent's Hospital,Darlinghurst, NSW 2010; Australia. TI - HIV-related oral disease. SO - Medical Journal of Australia Vol 158(2) (pp 109-110), 1993. AB - Oral lesions are frequently an early sign of HIV infection. However, without careful examination their significance can be missed, as they are often painless and discrete and may be the only sign of HIV infection. <97> UI - 1993034756 AU - Ciesielski C AU - Marianos D AU - Ou C-Y AU - Dumbaugh R AU - Witte J AU - Berkelman R AU - Gooch B AU - Myers G AU - Luo C-C AU - Schochetman G AU - Howell J AU - Lasch A AU - Bell K AU - Economou N AU - Scott B AU - Furman L AU - Curran J AU - Jaffe H IN - Division of HIV/AIDS, Centers for Disease Control, 1600 Clifton Road N.E.,Atlanta, GA 30333; United States. TI - Transmission of human immunodeficiency virus in a dental practice. SO - Annals of Internal Medicine Vol 116(10) (pp 798-805), 1992. AB - Objective: To determine if patients of a dentist with the acquired immunodeficiency syndrome (AIDS) became infected with human immunodeficiency virus (HIV) during their dental care and, if so, to identify possible mechanisms of transmission. Design: Retrospective epidemiologic follow-up of the dentist, his office practice, and his former patients. Setting: The practice of a dentist with AIDS in Florida. Participants: A dentist with AIDS, his health care providers and employees, and former patients of the dentist, including eight HIV-infected patients. Measurements: Identification of risks for HIV transmission (if present), degree of genetic relatedness of the viruses, and identification of infection control and other office practices. Results: Five of the eight HIV-infected patients had no confirmed exposures to HIV other than the dental practice and were infected with HIV strains that were closely related to those of the dentist. Each of the five had invasive dental procedures, done by the dentist after he was diagnosed with AIDS. Four of these five patients shared visit days (P > 0.2). Breaches in infection control and other dental office practices to explain these transmissions could not be identified. Conclusion: Although the specific incident that resulted in HIV transmission to these patients remains uncertain, the epidemiologic evidence supports direct dentist-to-patient transmission rather than a patient-to-patient route. <98> UI - 1993030692 AU - Ranta H AU - Lukinmaa P-L AU - Waltimo J IN - Department of Forensic Medicine, Kytosuontie 11,SF-00300 Helsinki; Finland. TI - Heritable dentin defects: Nosology, pathology, and treatment. SO - American Journal of Medical Genetics Vol 45(2) (pp 193-200), 1993. AB - Heritable dentin defects have been divided into 2 main categories: dentinogenesis imperfecta (DI) and dentin dysplasia (DD). Recent studies have shown that they share many features in common. Of the connective tissue diseases, only osteogenesis imperfecta (OI) has been linked to these disorders. So far, no definitive relation between the type of OI and the dental involvement can be established. Familial occurrence of DI with OI cannot be comprehensively explained by mutations in type I collagen genes. No information about the gene defects in DD is available. At the ultrastructural level, the organization of the normally cross-striated collagen fibers in the dentin matrix varies markedly in patients affected by DI. <99> UI - 1993006103 AU - Bonaventure J AU - Stanescu R AU - Stanescu V AU - Allain JC AU - Muriel MP AU - Ginisty D AU - Maroteaux P IN - CNRS URA 584, Clinique M. Lamy, Hopital des Enfants Malades, 149 rue de Sevres,75743 Paris Cedex 15; France. TI - Type II collagen defect in two sibs with the Goldblatt syndrome, a chondrodysplasia with dentinogenesis imperfecta, and joint laxity. SO - American Journal of Medical Genetics Vol 44(6) (pp 738-753), 1992. AB - We report on a syndrome of spondylo-epimetaphyseal dysplasia, dentinogenesis imperfecta, and ligamentous hyperextensibility in two sibs born to nonconsanguineous parents. This chondrodysplasia was characterized by severe shortness of stature and an osteoporosis without fractures. Electron microscopic examination of the cartilage documented large vacuoles of dilated rough endoplasmic reticulum within the cytoplasm of chondrocytes. Gel electrophoresis of pepsin-soluble collagen extracted from cartilage demonstrated the presence of type II collagen chains with an abnormal mobility. Prolyl and lysyl hydroxylations were slightly increased. The abnormal molecules melted at a higher temperature than the normal ones. CNBr peptide mapping of type II collagen showed an altered electrophoretic migration of peptides CB 11, CB 8, and CB 10,5 whereas CB 9,7 looked normal. In addition, two small non-collagenous proteins isolated from cartilage were not found in an age-matched control individual but were detected in a normal newborn infant. The quantitation of proline-labelled collagen synthesized by dermal fibroblasts demonstrated a 50% reduction of total collagen. This decrease essentially affected the amount of extracellular type I collagen, which was secreted less efficiently than in control cells. Nevertheless, type I collagen chains behaved normally on 5% polyacrylamide gels. The reduced mRNA levels of alpha1I and alpha2I chains might reflect either a transcriptional defect or a decreased stability of mRNA transcripts. We suggest that the association of both pathological chondrocytes producing altered collagen type II and decreased synthesis of type I could be responsible for this peculiar phenotype. The overmodification of alpha1II CNBr peptides is consistent with the presence of a single-base substitution in the COL2A1 gene. Whether there is a direct causal relationship between the type II collagen defect and the underexpression of type I collagen will require clarification. <100> UI - 1992369254 AU - Dichtel Jr WJ IN - Head/Neck Med./Surg. of SW Virginia, 102 Highland Avenue,Roanoke, VA 24013; United States. TI - Oral manifestations of human immunodeficiency virus infection. SO - Otolaryngologic Clinics of North America Vol 25(6) (pp 1211-1226), 1992. AB - Most HIV-infected individuals will demonstrate oral manifestations sometime during the course of their disease. These may be due to opportunistic infections in a compromised host, as in the case of the most common oral manifestation, oral Candida. Patients with AIDS may present with oral tumors such as KS of the oral cavity or oral lymphoma. A number of idiopathic oral conditions also are found in these individuals. Biopsy or culture of the lesions is frequently required to obtain the correct diagnosis. Treatment should be aimed as specifically as possible at the offending agent in the case of an infectious process or at the tumor. Supportive care and oral hygiene are imperative in all cases. Oral care should be coordinated with the patient's principal physician to obtain optimal results. <101> UI - 1992368613 AU - Kirch W AU - Duhrsen U IN - Medizinische Klinik, Christian-Albrechts-Universitat, Schittenhelmstrasse 12,W-2300 Kiel 1; Germany. TI - Erythema nodosum of dental origin. SO - Clinical Investigator Vol 70(12) (pp 1073-1078), 1992. AB - The association of erythema nodosum and dental infectious foci has rarely been described in the literature. This report concerns four women who developed erythema nodosum either following dental treatment associated with gingival bleeding or due to infectious dental foci. In these cases, tooth extraction, removal of dental deposits, interrupted pulp treatment, apical periodontitis, or a relicted root were identified as causes of the development of erythema nodosum. Upon admission to the hospital, these patients also presented fever and and a maximally elevated erythrocyte sedimentation rate (ESR). In all instances, surgical treatment of the dental foci and/or administration of antibiotics rapidly led to the regression of the erythema nodosum, as well as to the normalization of body temperature and ESR. The cases described indicate that antecedent dental treatment and the possible presence of infectious dental foci should be considered in the differential diagnosis of erythema nodosum when taking the patient's medical history. This approach may avoid unnecessary, possibly invasive diagnostic procedures and can lead to rapid improvement in the patient's clinical status. <102> UI - 1992365655 AU - Thorburn DN AU - Ferguson MM IN - Hospital Dental Services, Christchurch Hospital,4710 Christchurch; New Zealand. TI - Familial ogee roots, tooth mobility, oligodontia, and microdontia. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 74(5) (pp 576-581), 1992. <103> UI - 1992365654 AU - Van Loon LAJ AU - Bos JD AU - Davidson CL IN - Dental Materials Science Department, Dentistry Amsterdam Academic Centre, University of Amsterdam, Louwesweg 1,1066EA Amsterdam; Netherlands. TI - Clinical evaluation of fifty-six patients referred with symptoms tentatively related to allergic contact stomatitis. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 74(5) (pp 572-575), 1992. <104> UI - 1992363241 AU - Dean JS AU - Throckmorton GS AU - Ellis III E AU - Sinn DP IN - Oral/Maxillofacial Surgery Division, University of Texas SW Medical Ctr., 5323 Harry Hines Blvd,Dallas, TX 75235-9031; United States. TI - A preliminary study of maximum voluntary bite force and jaw muscle efficiency in pre-orthognathic surgery patients. SO - Journal of Oral & Maxillofacial Surgery Vol 50(12) (pp 1284-1288), 1992. AB - The functional state of dentofacial deformity patients before orthognathic surgery has received relatively little study. In this study, the ability to generate occlusal force was compared between 84 patients before treatment for various dentofacial deformities and 57 controls. Maximal and submaximal bite forces were measured at the incisor and right and left first molar bite positions. Electromyographic activity (EMG) was recorded bilaterally from the anterior temporalis, posterior temporalis, and masseter muscles during each bite. An efficiency ratio was calculated for the jaw muscles by dividing the level of EMG by the occlusal force. There was a reduced ability to generate occlusal forces in the patients before surgery, especially among female patients. The reductions in maximal occlusal force were correlated with reduced efficiency of the jaw muscles. <105> UI - 1992361659 AU - Aldred MJ AU - Crawford PJM AU - Roberts E AU - Gillespie CM AU - Thomas NST AU - Fenton I AU - Sandkuijl LA AU - Harper PS IN - Institute of Medical Genetics, Univ. of Wales College of Medicine, Heath Park,Cardiff CF4 4XN; United Kingdom. TI - Genetic heterogeneity in X-linked amelogenesis imperfecta. SO - Genomics Vol 14(3) (pp 567-573), 1992. AB - The AMELX gene located at Xp22.1-p22.3 encodes for the enamel protein amelogenin and has been implicated as the gene responsible for the inherited dental abnormality X-linked amelogenesis imperfecta (XAI). Three families with XAI have been investigated using polymorphic DNA markers flanking the position of AMELX. Using two-point linkage analysis, linkage was established between XAI and several of these markers in two families, with a combined lod score of 6.05 for DXS16 at theta = 0.04. This supports the involvement of AMELX, located close to DXS16, in the XAI disease process (AIH1) in those families. Using multipoint linkage analysis, the combined maximum lod score for these two families was 7.30 for a location of AIH1 at 2 cM distal to DXS16. The support interval around this location extended about 8 cM proximal to DXS92, and the AIH1 location could not be precisely defined by multipoint mapping. Study of recombination events indicated that AIH1 lies in the interval between DXS143 and DXS85. There was significant evidence against linkage to this region in the third family, indicating locus heterogeneity in XAI. Further analysis with markers on the long arm of the X chromosome showed evidence of linkage to DXS144E and F9 with no recombination with either of these markers. Two-point analysis gave a peak lod score at DXS144E with a maximum lod score of 2.83 at theta = 0, with a peak lod score in multipoint linkage analysis of 2.84 at theta = 0. The support interval extended 9 cM proximal to DXS144E and 14 cM distal to F9. Recombinations defined the localization of this second locus on the X chromosome causing XAI (AIH3) as Xq22-q28. This study demonstrates that there are at least two different loci on the X chromosome causing amelogenesis imperfecta, one on the distal short arm (AIH1) due to mutations in the AMELX gene and one on the long arm (AIH3) as a result of alterations in a gene in the Xq22-q28 region. <106> UI - 1992347029 AU - Teja Z AU - Persson R AU - Omnell L IN - Dental Department, Children's Hospital/Medical Center, 4800 Sandpoint Way NE,Seattle, WA 98105; United States. TI - Periodontal status of teeth adjacent to nongrafted unilateral alveolar clefts. SO - Cleft Palate-Craniofacial Journal Vol 29(4) (pp 357-362), 1992. AB - The purpose of this study was to compare the periodontal condition of teeth adjacent to the cleft with contralateral teeth in adult subjects with a nongrafted unilateral alveolar cleft. Periodontal parameters were evaluated in 18 subjects who had at least one tooth immediately adjacent to the cleft. For each tooth investigated, plaque index, gingival index, and probing depth were recorded and each tooth was assigned a mobility score. Width of attached gingiva and extent of recession was measured. Bone level was assessed using standardized magnified radiographs and a computerized digitizing system. The overall findings of this study support those of other studies and indicate that in individuals with a nongrafted alveolar cleft, teeth adjacent to the defect show signs of gingivitis but not of periodontal disease. The anatomic defect, eruption pattern, orthodontic tooth movements, and the presence of restorations appear to contribute to the reduced bone level on the central incisor adjacent to the cleft and to the presence of gingivitis. <107> UI - 1992336271 AU - Droz-DeSprez D AU - Azou C AU - Bordigoni P AU - Bonnaure-Mallet M IN - UER Odontologie, Rue du Docteur Heydenreich,54012 Nancy Cedex; France. TI - Infantile osteopetrosis: A case report on dental findings. SO - Journal of Oral Pathology & Medicine Vol 21(9) (pp 422-425), 1992. AB - In this paper we have described the case of a 7-yr-old Moroccan osteopetrotic boy, who had received a bone marrow transplant (BMT). He was transplanted from his older brother and, despite immunosuppressive therapy, developed chronic graft-versus-host disease and was placed on corticotherapy. Seven months after the bone marrow transplant, graft versus host disease (GVHD) was stabilized, but corticotherapy had inhibited growth. There was evidence of normalizing bone, his hearing was better but he had not recovered vision. Dental findings before the bone marrow transplant revealed some missing teeth, failure of teeth to erupt and decayed teeth but no enamel hypoplasia. The patient had developed one carious lesion on one unerupted tooth: bacteria seem to have found a way through the gubernaculum dentale. The scanning electronmicrographs showed decayed tooth and tissues fitted into each other. Since the bone marrow transplant, no tooth has erupted. We think that, in this case, failure of tooth eruption would be the sign of osteopetrosis. <108> UI - 1992336270 AU - Pope FM AU - Komorowska A AU - Lee KW AU - Speight P AU - Zorawska H AU - Ranta H AU - Coonar HS AU - MacKenzie JL IN - Clinical Research Centre, Watford Road,Harrow HA1 3UJ; United Kingdom. TI - Ehlers Danlos syndrome type I with novel dental features. SO - Journal of Oral Pathology & Medicine Vol 21(9) (pp 418-421), 1992. AB - The clinical, radiographic and histologic findings are described in two cases of Ehlers Danlos Syndrome Type I with novel dental features. Defective dentinogenesis principally affecting the mandibular incisors result in aplasia or hypoplasia of root development predisposing to localized periodontal disease. A striking radiographic appearance with a bulbous enlargement of the roots together with pulp stones is seen in other teeth. 'Giant channels' and vascular inclusions resembling 'intermediate cementum' are prominent within this area. No evidence of Type III procollagen or collagen was detected with indirect immunofluorescence. It is suggested that an inherited collagen abnormality in a component common to dentin, skin, ligament and tendon probably explains both EDS I and the dentin dysplasia. <109> UI - 1992327002 AU - Dardick KR IN - Connecticut Travel Medicine, Mansfield Professional Park,Storrs, CT 06268; United States. TI - General advice and medical kit. SO - Medical Clinics of North America Vol 76(6) (pp 1261-1276), 1992. AB - Physicians must be prepared to provide comprehensive pretravel advice to their patients. Because world conditions are constantly changing, it is necessary to obtain accurate and current information. Common health problems that may be faced by any traveler include accidents, motion sickness, and jet lag. Physicians must familiarize themselves with the many forms of insurance available for the traveler. <110> UI - 1992326187 AU - Ippel PF AU - Gorlin RJ AU - Lenz W AU - Van Doorne JM AU - Bijlsma JB IN - Clinical Genetics Center, State University Utrecht, P.O. Box 18009,3501 CA Utrecht; Netherlands. TI - Craniofacial dysostosis, hypertrichosis, genital hypoplasia, ocular, dental, and digital defects: Confirmation of the Gorlin-Chaudhry-Moss syndrome. SO - American Journal of Medical Genetics Vol 44(4) (pp 518-522), 1992. AB - We report clinical, orofacial and radiological manifestations in a 4-year- old girl and a 33-year-old female with the Gorlin-Chaudhry-Moss (GCM) syndrome. Typical findings in the GCM syndrome are short stature, stocky body build, midface hypoplasia, small eyes, downslanting palpebral fissures, conductive hearing loss, highly arched and narrow palate, malocclusion, abnormally shaped teeth, oligodontia, microdontia, low scalp hairline, hypertrichosis of scalp, face, trunk and limbs and genital hypoplasia. Radiological features include premature synostosis of the coronal suture, brachycephaly, and maxillary underdevelopment. Hypoplasia of the distal phalanges of fingers and toes (also present in the 2 original cases) represents a further manifestation of the GCM syndrome. <111> UI - 1992307714 AU - Mass E AU - Sarnat H AU - Ram D AU - Gadoth N IN - Department of Pediatric Dentistry, M./G. Goldschleger Dental Med. Sch., Tel Aviv University,Tel Aviv; Israel. TI - Dental and oral findings in patients with familial dysautonomia. SO - Oral Surgery, Oral Medicine, Oral Pathology Vol 74(3) (pp 305-311), 1992. <112> UI - 1992305902 AU - Yetter III JF IN - Madigan Army Medical Center,Tacoma, WA; United States. TI - Cleft lip and cleft palate. SO - American Family Physician Vol 46(4) (pp 1211-1220), 1992. AB - The birth of a child with a cleft lip or a cleft palate, or both, can be traumatic to the family. Although referral to a multidisciplinary team experienced in craniofacial abnormalities is essential, the family physician can reduce the impact on the family by providing antenatal diagnosis and continued care of the entire family after diagnosis, during initial feeding and bonding difficulties and throughout the many years of surgical and speech therapy. <113> UI - 1992294017 AU - Harrison JW IN - 766 Liberty Street,Meadville, PA 16335; United States. TI - Dental implants to rehabilitate a patient with an unrepaired complete cleft of the hard and soft palate: A clinical report. SO - Cleft Palate-Craniofacial Journal Vol 29(5) (pp 485-488), 1992. AB - Prosthetic rehabilitation of an edentulous adult with a complete residual cleft of his palates is presented. Lack of retention of his prosthesis made speech and eating difficult. Four osseointegrated dental implants were used to join the right and left maxillae and to provide mechanical retention for a complete overdenture obturator to improve function. <114> UI - 1992290282 AU - Karnitis SA AU - Burns K AU - Sudduth KW AU - Golden WL AU - Wilson WG IN - Virginia Univ. Health Sciences Ctr., Box 386,Charlottesville, VA 22908; United States. TI - Deletion (14) (q24.3q32.1): Evidence for a distinct clinical phenotype. SO - American Journal of Medical Genetics Vol 44(2) (pp 153-157), 1992. AB - We report on a 4-year-old girl with distinctive facial features (redundant skin, bushy eyebrows, narrow palpebral fissures, short, up-turned nose, epicanthal folds, and a long upper lip with well-defined philtrum) who has an interstitial deletion of chromosome 14 including band 14q31, designated as 46,XX,del(14)(pter [right arrow] q24.3::q32.1 [right arrow] qter). Comparison with previously reported patients with deletions of 14q